CXCL10

CXCL10
Struktur yang tersedia PDB Pencarian Ortolog: PDBe RCSB Daftar kode id PDB 1O80, 1LV9, 1O7Y, 1O7Z
Pengidentifikasi
Alias	CXCL10, C7, IFI10, INP10, IP-10, SCYB10, crg-2, gIP-10, mob-1, C-X-C motif chemokine ligand 10, C-X-C motif chemokine 10
ID eksternal	OMIM: 147310 MGI: 1352450 HomoloGene: 1203 GeneCards: CXCL10
Lokasi gen (Tikus) Kr. Kromosom 5 (tikus) Pita 5 E2|5 46.57 cM Awal 92,494,497 bp Akhir 92,496,748 bp
Pola ekspresi RNA Referensi data ekspresi selengkapnya
Ontologi gen Fungsi molekuler • cytokine activity • heparin binding • CXCR3 chemokine receptor binding • chemokine activity • GO:0001948, GO:0016582 Ikatan protein plasma • cAMP-dependent protein kinase regulator activity • signaling receptor binding • chemoattractant activity Komponen seluler • extracellular region • external side of plasma membrane • extracellular space • intracellular anatomical structure Proses biologis • regulation of endothelial tube morphogenesis • negative regulation of myoblast differentiation • cellular response to heat • respons terhadap vitamin D • positive regulation of cell migration • T cell chemotaxis • chemokine-mediated signaling pathway • cell-cell signaling • response to virus • muscle organ development • positive regulation of monocyte chemotaxis • positive regulation of release of sequestered calcium ion into cytosol • endothelial cell activation • positive regulation of cAMP-mediated signaling • regulation of T cell chemotaxis • blood circulation • chemotaxis • positive regulation of leukocyte chemotaxis • cell surface receptor signaling pathway • response to lipopolysaccharide • negative regulation of myoblast fusion • defense response to virus • regulation of cell population proliferation • GO:0046730, GO:0046737, GO:0046738, GO:0046736 respons imun • positive regulation of cell population proliferation • response to auditory stimulus • negative regulation of angiogenesis • response to cold • cellular response to lipopolysaccharide • response to gamma radiation • positive regulation of T cell migration • GO:0072468 signal transduction • GO:0003257, GO:0010735, GO:1901228, GO:1900622, GO:1904488 positive regulation of transcription by RNA polymerase II • regulation of protein kinase activity • defense response • inflammatory response • antimicrobial humoral immune response mediated by antimicrobial peptide • regulation of signaling receptor activity • G protein-coupled receptor signaling pathway • cytokine-mediated signaling pathway • adenylate cyclase-activating G protein-coupled receptor signaling pathway • response to bacterium • neutrophil chemotaxis • leukocyte chemotaxis • positive chemotaxis • regulation of apoptotic process Sumber:Amigo / QuickGO
Ortolog
Spesies	Manusia	Tikus
Entrez	3627	15945
Ensembl	ENSG00000169245	ENSMUSG00000034855
UniProt	P02778	P17515
RefSeq (mRNA)	NM_001565	NM_021274
RefSeq (protein)	NP_001556	NP_067249
Lokasi (UCSC)	n/a	Chr 5: 92.49 – 92.5 Mb
Pencarian PubMed
Wikidata
Lihat/Sunting Manusia Lihat/Sunting Tikus

CXCL10 (bahasa Inggris: interferon-gamma induced protein, γ-IP10, IP-10) adalah kemokina bermotif C-X-C dengan ligan 10, dan mempunyai massa 10 kDa.

IP-10 disekresi oleh beberapa sel sebagai respon terhadap hormon IFN-γ, termasuk monosit, sel endotelial, dan fibroblas.

IP-10 diketahui turut berperan sebagai:

• mediator kemotaksis bagi monosit, makrofaga, sel T, sel NK dan DC
• stimulan adhesi sel T ke sel endotelial
• aktivitas anti-tumor
• inhibitor pembentukan koloni pada sumsum tulang dan proses angiogenesis, setelah mengikatkan dirinya pada permukaan sel pada pencerap kemokina CXCR3.

Gen IP-10 terletak pada kromosom 4 pada kluster yang bersamaan dengan beberapa kemokina CXC lainnya.