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IL4 Struktur yang tersedia PDB Pencarian Ortolog: PDBe RCSB Daftar kode id PDB 1BBN , 1BCN , 1CYL , 1HIJ , 1HIK , 1HZI , 1IAR , 1ITI , 1ITL , 1ITM , 1RCB , 2B8U , 2B8X , 2B8Y , 2B8Z , 2B90 , 2B91 , 2CYK , 2D48 , 2INT , 3BPL , 3BPN , 3QB7 , 4YDY , 5FHX
Pengidentifikasi Alias IL4 ID eksternal MGI: 96556 HomoloGene: 491 GeneCards: IL4 Lokasi gen (Tikus) Kr. Kromosom 11 (tikus)[ 1] Pita 11 B1.3|11 31.97 cM Awal 53,493,809 bp [ 1] Akhir 53,509,496 bp [ 1]
Ontologi gen Fungsi molekuler • interleukin-4 receptor binding • GO:0001948, GO:0016582 Ikatan protein plasma • growth factor activity • GO:0005145 cytokine receptor binding • cytokine activity Komponen seluler • extracellular region • extracellular space Proses biologis • positive regulation of T cell differentiation • dendritic cell differentiation • negative regulation of endothelial cell apoptotic process • negative regulation of complement-dependent cytotoxicity • regulation of phosphorylation • negative regulation of apoptotic process • myeloid dendritic cell differentiation • type 2 immune response • B cell activation • positive regulation of interleukin-13 production • GO:0046730, GO:0046737, GO:0046738, GO:0046736 respons imun • B cell differentiation • T-helper 2 cell cytokine production • regulation of isotype switching • GO:0045996 negative regulation of transcription, DNA-templated • negative regulation of epithelial cell migration • regulation of signaling receptor activity • cholesterol metabolic process • positive regulation of B cell proliferation • positive regulation of T cell proliferation • T cell activation • positive regulation of MHC class II biosynthetic process • negative regulation of osteoclast differentiation • GO:0060469, GO:0009371 positive regulation of transcription, DNA-templated • GO:0003257, GO:0010735, GO:1901228, GO:1900622, GO:1904488 positive regulation of transcription by RNA polymerase II • positive regulation of isotype switching to IgE isotypes • positive regulation of isotype switching to IgG isotypes • regulation of immune response • cytokine-mediated signaling pathway • GO:1901313 positive regulation of gene expression • positive regulation of macroautophagy • positive regulation of tyrosine phosphorylation of STAT protein • activation of Janus kinase activity • positive regulation of receptor-mediated endocytosis • positive regulation of cold-induced thermogenesis • negative regulation of neuroinflammatory response • positive regulation of amyloid-beta clearance • neuroinflammatory response • positive regulation of cellular respiration • positive regulation of ATP biosynthetic process Sumber:Amigo / QuickGO
Ortolog Spesies Manusia Tikus Entrez Ensembl UniProt RefSeq (mRNA) RefSeq (protein) Lokasi (UCSC) n/a Chr 11: 53.49 – 53.51 Mb Pencarian PubMed [ 2] [ 3] Wikidata
Interleukin-4 , IL-4 (bahasa Inggris : BSF1, BCGF1, BCGF-1, MGC79402 sitokina pleiotropik yang disekresi oleh sel T yang telah teraktivasi[ 4] H 2, bersama-sama dengan IL-5 dan IL-13 .[ 5] sistem kekebalan dan merupakan faktor yang penting dalam perkembangan hipersensitivitas ,[ 6] IL-13 .[ 4]
^ a b c GRCm38: Ensembl release 89: ENSMUSG00000000869 - Ensembl , May 2017^ "Human PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .^ "Mouse PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .^ a b (Inggris) "IL4 interleukin 4 [ Homo sapiens ]" . Entrez Gene . Diakses tanggal 2010-06-09 .^ (Inggris) "Inflammatory cytokines (IL-4, IL-5 and IL-13)" . Clinical Research Center, National Sagamihara Hospital; Maeda S, Yanagihara Y . Diakses tanggal 2010-06-09 .^ (Inggris) "A modular interface of IL-4 allows for scalable affinity without affecting specificity for the IL-4 receptor" . Lehrstuhl für Physiologische Chemie II, Theodor-Boveri Institut für Biowissenschaften (Biozentrum) der Universität Würzburg; Kraich M, Klein M, Patiño E, Harrer H, Nickel J, Sebald W, Mueller TD . Diakses tanggal 2010-06-09 .
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