Asam flufenamat
Dari Wikipedia bahasa Indonesia, ensiklopedia bebas
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| Nama sistematis (IUPAC) | |
| 2-{[3-(Trifluoromethyl)phenyl]amino}benzoic acid | |
| Data klinis | |
| Kat. kehamilan | ? |
| Status hukum | ? |
| Rute | oral, topical |
| Pharmacokinetic data | |
| Ikatan protein | extensively |
| Metabolisme | Hydroxylation, glucuronidation |
| Waktu paruh | ~3 h |
| Ekskresi | 50% urine, 36% feces |
| Pengenal | |
| Nomor CAS | 530-78-9 |
| Kode ATC | M01AG03 |
| PubChem | CID 3371 |
| Ligan IUPHAR | 2447 |
| ChemSpider | 3254  |
| UNII | 60GCX7Y6BH |
| KEGG | D01581 |
| ChEMBL | CHEMBL23588 |
| Data kimia | |
| Formula | C14H10F3NO2 |
| Massa mol. | 281.22991 g/mol |
| SMILES | eMolecules & PubChem |
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| Data fisik | |
| Titik lebur | 124–125 °C (255–257 °F) resolidification and remelting at 134 °C to 136 °C |
| Kelarutan dalam air | Practically insoluble in water; soluble in ethanol, chloroform and diethyl ether mg/mL (20 °C) |
Asam flufenamat (bahasa Inggris: flufenamic acid, FLF) adalah senyawa organik non-steroid dari golongan asam fenamat yang bersifat anti-peradangan. Asam flufenamat telah lama digunakan untuk menghambat terserapnya ion Ca2+ melalui transient receptor potential channels (TRPC), dan menginduksi pelepasan Ca2+ dari mitokondria.[1] Selain itu, FLF juga menghambat transkripsi pencerap androgen dan memberi pengaruh genetik terhadap gen pencerap tersebut.[2]
[sunting] Rujukan
- ^ (Inggris)"Functional distinctions in cytosolic calcium regulation between cells of the glomerular filtration barrier". Academic Renal Unit, Southmead Hospital, Microvascular Research Laboratories, Department of Physiology, University of Bristol; Rebecca Rachael Foster, Gavin I. Welsh, Simon C. Satchell, Robin D. Marlow, Mathew D. Wherlock, Debora Pons, Peter W. Mathieson, David O. Bates, dan Moin A. Saleem. http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2937225. Diakses pada 8 Juni 2011.
- ^ (Inggris)"Novel Flufenamic Acid Analogs as Inhibitors of Androgen Receptor Mediated Transcription". Department of Chemical Biology and Therapeutics, St Jude Children's Research Hospital; Clémentine Féau, Leggy A. Arnold, Aaron Kosinski, Fangyi Zhu, Michele Connelly, dan R. Kiplin Guy. http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2763043. Diakses pada 8 Juni 2011.
