Flutikason

Flutikason
Nama sistematis (IUPAC)
	S-fluorometil (6S,8S,9R,10S,11S,13S,14S,16R,17R)-6,9-difluoro-11,17-dihidroksi-10,13,16-trimetil-3-okso-6,7,8,11,12,14,15,16-oktahidrosiklopenta[a]fenantrena-17-karbotioat
Data klinis
Kat. kehamilan	?
Status hukum	OTC (CA)
Rute	Intranasal, inhalasi, Topikal
Data farmakokinetik
Bioavailabilitas	0.51% (Intranasal)
Ikatan protein	91.0%
Metabolisme	Intranasal; Hati (CYP3A4-dimediasi)
Waktu paruh	10 jam
Ekskresi	Ginjal
Pengenal
Nomor CAS	90566-53-3
Kode ATC	D07AC17 R01AD08 R03BA05 R01AD58
PubChem	CID 5311101
Ligan IUPHAR	6699
DrugBank	DB00588
ChemSpider	4470631
UNII	CUT2W21N7U
KEGG	D07981
ChEBI	CHEBI:5134
ChEMBL	CHEMBL1201396
Sinonim	6α,9α-Difluoro-11β,17α-dihidroksi-16α-metil-21-tia-21-fluorometilpregna-1,4-dien-3,20-diona; S-(Fluorometil)-6α,9α-difluoro-11β,17α-dihidroksi-16α-metil-3-oksoandrosta-1,4-diena-17β-karbotioat
Data kimia
Rumus	C22H27F3O4S
	InChI InChI=1S/C22H27F3O4S/c1-11-6-13-14-8-16(24)15-7-12(26)4-5-19(15,2)21(14,25)17(27)9-20(13,3)22(11,29)18(28)30-10-23/h4-5,7,11,13-14,16-17,27,29H,6,8-10H2,1-3H3/t11-,13+,14+,16+,17+,19+,20+,21+,22+/m1/s1 ; Key:MGNNYOODZCAHBA-GQKYHHCASA-N ;

Flutikason adalah senyawa glukokortikoid yang digunakan untuk mengobati gejala penyakit rongga hidung.^[1]^[2]^[3]^[4]^[5] Baik esternya yakni flutikason propionat dan flutikason furoat, juga digunakan sebagai antiinflamasi topikal dan kortikosteroid inhalasi, dan lebih sering digunakan sebagai perbandingan.^[3]^[2]^[4]^[6]

Obat ini ada dalam Daftar Obat Esensial Organisasi Kesehatan Dunia.^[7] Pada tahun 2021, obat ini merupakan obat ke-23 yang paling sering diresepkan di Amerika Serikat, dengan lebih dari 25 juta resep,^[8]^[9] meskipun obat ini juga dijual bebas.^[10]

Referensi[sunting | sunting sumber]

^ Elks J (14 November 2014). The Dictionary of Drugs: Chemical Data: Chemical Data, Structures and Bibliographies. Springer. hlm. 574–. ISBN 978-1-4757-2085-3.
^ ^a ^b Index Nominum 2000: International Drug Directory. Taylor & Francis. 2000. hlm. 1337–. ISBN 978-3-88763-075-1.
^ ^a ^b Morton IK, Hall JM (6 December 2012). Concise Dictionary of Pharmacological Agents: Properties and Synonyms. Springer Science & Business Media. hlm. 124–. ISBN 978-94-011-4439-1.
^ ^a ^b "Fluticasone - FDA prescribing information, side effects and uses".
^ Briggs GG, Freeman RK, Yaffe SJ (2012). Drugs in Pregnancy and Lactation: A Reference Guide to Fetal and Neonatal Risk. Lippincott Williams & Wilkins. hlm. 600. ISBN 978-1451153590.
^ Spratto GR, Woods AL (2012). Delmar Nurse's Drug Handbook 2012. Cengage Learning. hlm. 748. ISBN 978-1111310653.
^ World Health Organization (2021). World Health Organization model list of essential medicines: 22nd list (2021). Geneva: World Health Organization. hdl:10665/345533 . WHO/MHP/HPS/EML/2021.02.
^ "The Top 300 of 2021". ClinCalc. Diarsipkan dari versi asli tanggal 15 January 2024. Diakses tanggal 14 January 2024.
^ "Fluticasone - Drug Usage Statistics". ClinCalc. Diakses tanggal 14 January 2024.
^ "Fluticasone Nasal Spray". Diakses tanggal 21 October 2022.

[Elks2014-1] Elks J (14 November 2014). The Dictionary of Drugs: Chemical Data: Chemical Data, Structures and Bibliographies. Springer. hlm. 574–. ISBN 978-1-4757-2085-3.

[IndexNominum2000-2] Index Nominum 2000: International Drug Directory. Taylor & Francis. 2000. hlm. 1337–. ISBN 978-3-88763-075-1.

[MortonHall2012-3] Morton IK, Hall JM (6 December 2012). Concise Dictionary of Pharmacological Agents: Properties and Synonyms. Springer Science & Business Media. hlm. 124–. ISBN 978-94-011-4439-1.

[Drugs.com-4] "Fluticasone - FDA prescribing information, side effects and uses".

[Briggs_et_al2012-5] Briggs GG, Freeman RK, Yaffe SJ (2012). Drugs in Pregnancy and Lactation: A Reference Guide to Fetal and Neonatal Risk. Lippincott Williams & Wilkins. hlm. 600. ISBN 978-1451153590.

[SprattoWoods2012-6] Spratto GR, Woods AL (2012). Delmar Nurse's Drug Handbook 2012. Cengage Learning. hlm. 748. ISBN 978-1111310653.

[WHO22nd-7] World Health Organization (2021). World Health Organization model list of essential medicines: 22nd list (2021). Geneva: World Health Organization. hdl:10665/345533 . WHO/MHP/HPS/EML/2021.02.

[8] "The Top 300 of 2021". ClinCalc. Diarsipkan dari versi asli tanggal 15 January 2024. Diakses tanggal 14 January 2024.

[9] "Fluticasone - Drug Usage Statistics". ClinCalc. Diakses tanggal 14 January 2024.

[10] "Fluticasone Nasal Spray". Diakses tanggal 21 October 2022.

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