Donepezil

Donepezil
Nama sistematis (IUPAC)
	(RS)-2-[(1-Benzyl-4-piperidyl)methyl]-5,6-dimethoxy-2,3-dihydroinden-1-one
Data klinis
Nama dagang	Aricept, others
AHFS/Drugs.com	monograph
MedlinePlus	a697032
Data lisensi	US Daily Med:pranala
Kat. kehamilan	B3(AU) C(US)
Status hukum	Harus dengan resep dokter (S4) (AU) ℞-only (US) ℞ Preskripsi saja
Rute	By mouth (tablets) Absorption is not affected by food or time of day.
Data farmakokinetik
Bioavailabilitas	100%
Ikatan protein	96%, albumin (about 75%) and alpha1-acid glycoprotein (21%).
Metabolisme	CYP2D6, CYP3A4, and glucuronidation. Four major metabolites, two of which are active.
Waktu paruh	70 hours Around 100 hours in elderly patients.
Ekskresi	0.11–0.13 (L/h/kg); excreted mostly by the kidneys. Around 17% is excreted unchanged in the urine. About 15% to 20% is excreted in feces. Steady-state clearance is similar at all ages.
Pengenal
Kode ATC	?
Data kimia
Rumus	C24H29NO3
SMILES	eMolecules & PubChem
	InChI InChI=1S/C24H29NO3/c1-27-22-14-19-13-20(24(26)21(19)15-23(22)28-2)12-17-8-10-25(11-9-17)16-18-6-4-3-5-7-18/h3-7,14-15,17,20H,8-13,16H2,1-2H3 ; Key:ADEBPBSSDYVVLD-UHFFFAOYSA-N ;

Donepezil adalah obat yang digunakan untuk mengatasipenyakit Alzheimer . ^[4] Donepezil bisa memberikan cukup manfaat untuk fungsi mental. ^[5] Sayangnya penggunaan obat ini masih belum terbukti dalam mengubah penyakit alzheimer. ^[6] Penggunaan harus dihentikan jika tidak memiliki manfaat atau perubahan yang terlihat. ^[7] Rute pemberian obat ini melalui oral. ^[4]

Kejadian efek samping yang umum pada penggunaan obat ini seperti , rasa lelah,sulit tidur, agresi, diare, mual dan kram otot. ^[4] ^[7] Kejadian efek samping yang serius pada penggunaan obat ini meliputi aritmia, retensi urin, dan sawan . ^[4] Obati ini merupakan golongan inhibitor asetilkolinesterase reversibel yang memiliki mekanisme kerja secara terpusat dan secara struktural tidak berkaitan dengan agen antikolinesterase lainnya. ^[4] ^[1]

Obat donepezil disetujui dalam penggunaan medis di Amerika Serikat pada tahun 1996. ^[4] Donepezil sudah tersedia dalam bentuk obat generik. ^[7]

Referensi[sunting | sunting sumber]

^ ^a ^b ^c ^d ^e ^f ^g ^h ⁱ Kumar, A; Sharma, S (2020), "article-20656", Donepezil, Treasure Island (FL): StatPearls Publishing, PMID 30020629, diarsipkan dari versi asli tanggal 2021-08-28, diakses tanggal 2020-04-12
^ ^a ^b ^c ^d Seltzer, Ben (2005-09-29). "Donepezil: a review". Expert Opinion on Drug Metabolism & Toxicology. Informa Healthcare. 1 (3): 527–36. doi:10.1517/17425255.1.3.527. ISSN 1742-5255. PMID 16863459. there is a linear relationship between dose and pharmacodynamic effects, measured as red blood cell acetylcholinesterase inhibition and clinical efficacy. Despite being 96% bound to plasma proteins, it has few interactions with other drugs, and the 5-mg dose can be given safely to patients with mild-to-moderate hepatic and renal-disease.
^ Asiri, Yousif A.; Mostafa, Gamal A.E. (2010). "Donepezil". Profiles of Drug Substances, Excipients and Related Methodology. 35. Elsevier. hlm. 117–50. doi:10.1016/s1871-5125(10)35003-5. ISBN 978-0-12-380884-4. ISSN 1871-5125. PMID 22469221. Plasma donepezil concentrations decline with a half-life of approximately 70 h. Sex, race, and smoking history have no clinically significant influence on plasma concentrations of donepezil [46–51].
^ ^a ^b ^c ^d ^e ^f "Donepezil Hydrochloride Monograph for Professionals". Drugs.com (dalam bahasa Inggris). American Society of Health-System Pharmacists. Diarsipkan dari versi asli tanggal 26 July 2019. Diakses tanggal 4 February 2019.
^ Birks JS, Harvey RJ (June 2018). "Donepezil for dementia due to Alzheimer's disease". The Cochrane Database of Systematic Reviews. 6: CD001190. doi:10.1002/14651858.CD001190.pub3. PMC 6513124 . PMID 29923184.
^ Swedish Council on Health Technology Assessment (June 2008). "Dementia – Caring, Ethics, Ethnical and Economical Aspects: A Systematic Review". PMID 28876770.
^ ^a ^b ^c British national formulary : BNF 76 (edisi ke-76). Pharmaceutical Press. 2018. hlm. 300. ISBN 9780857113382.

[Kum2020-1] ^ ^a ^b ^c ^d ^e ^f ^g ^h ⁱ Kumar, A; Sharma, S (2020), "article-20656", Donepezil, Treasure Island (FL): StatPearls Publishing, PMID 30020629, diarsipkan dari versi asli tanggal 2021-08-28, diakses tanggal 2020-04-12

[Seltzer_2005_pp._527–536-2] Seltzer, Ben (2005-09-29). "Donepezil: a review". Expert Opinion on Drug Metabolism & Toxicology. Informa Healthcare. 1 (3): 527–36. doi:10.1517/17425255.1.3.527. ISSN 1742-5255. PMID 16863459. there is a linear relationship between dose and pharmacodynamic effects, measured as red blood cell acetylcholinesterase inhibition and clinical efficacy. Despite being 96% bound to plasma proteins, it has few interactions with other drugs, and the 5-mg dose can be given safely to patients with mild-to-moderate hepatic and renal-disease.

[Asiri_Mostafa_2010_pp._117–150-3] Asiri, Yousif A.; Mostafa, Gamal A.E. (2010). "Donepezil". Profiles of Drug Substances, Excipients and Related Methodology. 35. Elsevier. hlm. 117–50. doi:10.1016/s1871-5125(10)35003-5. ISBN 978-0-12-380884-4. ISSN 1871-5125. PMID 22469221. Plasma donepezil concentrations decline with a half-life of approximately 70 h. Sex, race, and smoking history have no clinically significant influence on plasma concentrations of donepezil [46–51].

[AHFS2019-4] ^ ^a ^b ^c ^d ^e ^f "Donepezil Hydrochloride Monograph for Professionals". Drugs.com (dalam bahasa Inggris). American Society of Health-System Pharmacists. Diarsipkan dari versi asli tanggal 26 July 2019. Diakses tanggal 4 February 2019.

[5] Birks JS, Harvey RJ (June 2018). "Donepezil for dementia due to Alzheimer's disease". The Cochrane Database of Systematic Reviews. 6: CD001190. doi:10.1002/14651858.CD001190.pub3. PMC 6513124 . PMID 29923184.

[6] Swedish Council on Health Technology Assessment (June 2008). "Dementia – Caring, Ethics, Ethnical and Economical Aspects: A Systematic Review". PMID 28876770.

[BNF76-7] British national formulary : BNF 76 (edisi ke-76). Pharmaceutical Press. 2018. hlm. 300. ISBN 9780857113382.

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