Akuaporin 1

AQP1
Struktur yang tersedia
PDB	Pencarian Ortolog: PDBe RCSB
Daftar kode id PDB
	4CSK, 1FQY, 1H6I, 1IH5
Pengidentifikasi
Alias	AQP1, AQP-CHIP, CHIP28, CO, aquaporin 1 (Colton blood group)
ID eksternal	OMIM: 107776 MGI: 103201 HomoloGene: 68051 GeneCards: AQP1
Lokasi gen (Tikus)
Kr.	Kromosom 6 (tikus)
Akhir	55,325,540 bp
Pola ekspresi RNA
	; ;
	Referensi data ekspresi selengkapnya
Ontologi gen
Fungsi molekuler	• aktivitas transporter; • GO:0051739, GO:0015251 aktivitas transporter transmembran amonium; • aktivitas transporter transmembran nitrogen monoksida; • aktivitas saluran kation teraktivasi cGMP intraseluler; • aktivitas saluran kalium; • GO:0022891 aktivitas transporter transmembran; • aktivitas transporter transmembran karbon dioksida; • GO:0001948, GO:0016582 Ikatan protein plasma; • aktivitas transporter transmembran air; • GO:0015388 aktivitas transporter transmembran ion kalium; • aktivitas transporter transmembran gliserol; • aktivitas saluran air; • pengikatan reseptor efrin; • pengikatan protein identik; • aktivitas saluran;
Komponen seluler	• sitoplasma; • membran inti; • symbiont-containing vacuole membrane; • membran; • Inti sel; • membran plasma apikal; • komponen integral membran; • Membran sel; • apical part of cell; • basal plasma membrane; • integral component of plasma membrane; • brush border membrane; • membran plasma basolateral; • Sarkolema; • brush border; • symbiont-containing vacuole; • Akson; • neuron projection; • axon terminus; • extracellular exosome;
Proses biologis	• cellular response to retinoic acid; • cellular response to mechanical stimulus; • cellular response to copper ion; • cellular response to nitric oxide; • respons seluler terhadap hipoksia; • cellular response to cAMP; • carbon dioxide transmembrane transport; • positive regulation of fibroblast proliferation; • cellular homeostasis; • pancreatic juice secretion; • cGMP biosynthetic process; • cellular response to stress; • cellular response to salt stress; • cellular response to inorganic substance; • cell volume homeostasis; • cellular response to UV; • establishment or maintenance of actin cytoskeleton polarity; • negative regulation of apoptotic process; • cellular response to dexamethasone stimulus; • positive regulation of angiogenesis; • odontogenesis; • renal water transport; • negative regulation of cysteine-type endopeptidase activity involved in apoptotic process; • cellular response to mercury ion; • nitric oxide transport; • cellular hyperosmotic response; • bicarbonate transport; • positive regulation of saliva secretion; • renal water homeostasis; • multicellular organismal water homeostasis; • transepithelial water transport; • carbon dioxide transport; • cellular response to hydrogen peroxide; • cerebrospinal fluid secretion; • potassium ion transmembrane transport; • ammonium transmembrane transport; • cation transmembrane transport; • glomerular filtration; • potassium ion transport; • transpor air; • hyperosmotic response; • response to hormone; • positive regulation of lamellipodium assembly; • positive regulation of epithelial cell migration; • glycerol transport; • Nosisepsi; • lateral ventricle development; • water homeostasis; • positive regulation of cell migration; • secretion by cell; • secretory granule organization; • wound healing; • hyperosmotic salinity response; • response to estrogen; • lipid digestion; • camera-type eye morphogenesis; • corticotropin secretion; • renal water absorption; • metanephric descending thin limb development; • metanephric proximal straight tubule development; • metanephric proximal convoluted tubule segment 2 development; • metanephric glomerulus vasculature development; • GO:0015915 transpor; • cGMP-mediated signaling; • ion transmembrane transport; • transpor transmembran;
	Sumber:Amigo / QuickGO
Ortolog
	358
	11826
	ENSG00000240583
	ENSMUSG00000004655
	P29972; Q6JSD8; Q6JSD7
	Q02013
NM_198098; NM_000385; NM_001185060; NM_001185061; NM_001185062;
	NM_001329872
	NM_007472
	NP_001316801; NP_932766
	NP_031498
	Wikidata
Lihat/Sunting Manusia	Lihat/Sunting Tikus

Akuaporin 1 adalah protein pada manusia yang dikodekan oleh gen AQP1.

AQP1 secara luas mengekspresikan saluran air yang fungsi fisiologisnya banyak dikarakteristikkan di dalam ginjal. Protein ini ditemukan pada membran plasma basolateral dan apikal tubulus proksimal, lengan menurun lengkung Henle, dan pada bagian menurun vasa rekta. Sebagai tambahan, protein ini juga ditemukan pada sel darah merah, endotelium vaskular, saluran pencernaan, kelenjar keringat, dan paru-paru.

Akuaporin ini tidak diregulasi oleh vasopresin (ADH).

Fungsi[sunting | sunting sumber]

Akuaporin merupakan famili protein membran integral kecil terkait protein intrinsik mayor (MIP atau AQP0). Gen ini mengodekan akuaporin yang berfungsi sebagai protein saluran air molekuler. Protein ini merupakan homotetramer dengan 6 domain rentangan dwilapis dan situs N-glikosilasi. Fisik protein menyerupai protein saluran dan melimpah pada eritrosit dan tubulus ginjal. Gen yang mengodekan akuaporin ini menjadi kandidat mungkin untuk kelainan yang melibatkan ketidakseimbangan pada pergerakan cairan okular.^[4]

Lihat juga[sunting | sunting sumber]

Referensi[sunting | sunting sumber]

^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000004655 - Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Entrez Gene: AQP1 aquaporin 1 (Colton blood group)".

Bacaan lanjutan[sunting | sunting sumber]

Knepper MA (1994). "The aquaporin family of molecular water channels". Proc. Natl. Acad. Sci. U.S.A. 91 (14): 6255–8. doi:10.1073/pnas.91.14.6255. PMC 44179 . PMID 7517546.
Borgnia M, Nielsen S, Engel A, Agre P (2000). "Cellular and molecular biology of the aquaporin water channels". Annu. Rev. Biochem. 68: 425–58. doi:10.1146/annurev.biochem.68.1.425. PMID 10872456.
Horster M (2001). "Embryonic epithelial membrane transporters". Am. J. Physiol. Renal Physiol. 279 (6): F982–96. PMID 11097616.
Yool AJ, Weinstein AM (2002). "New roles for old holes: ion channel function in aquaporin-1". News Physiol. Sci. 17: 68–72. PMID 11909995.
Mitra AK, Ren G, Reddy VS, Cheng A, Froger A (2002). "The architecture of a water-selective pore in the lipid bilayer visualized by electron crystallography in vitreous ice". Novartis Found. Symp. Novartis Foundation Symposia. 245: 33–46; discussion 46–50; 165–8. doi:10.1002/0470868759.ch4. ISBN 978-0-470-86875-1. PMID 12027013.
Ripoche P, Goossens D, Devuyst O, Gane P, Colin Y, Verkman AS, Cartron JP (2006). "Role of RhAG and AQP1 in NH₃ and CO₂ gas transport in red cell ghosts: a stopped-flow analysis". Transfusion clinique et biologique : journal de la Société française de transfusion sanguine. 13 (1–2): 117–22. doi:10.1016/j.tracli.2006.03.004. PMID 16574458.
Preston GM, Carroll TP, Guggino WB, Agre P (1992). "Appearance of water channels in Xenopus oocytes expressing red cell CHIP28 protein". Science. 256 (5055): 385–7. doi:10.1126/science.256.5055.385. PMID 1373524.
Preston GM, Agre P (1992). "Isolation of the cDNA for erythrocyte integral membrane protein of 28 kilodaltons: member of an ancient channel family". Proc. Natl. Acad. Sci. U.S.A. 88 (24): 11110–4. doi:10.1073/pnas.88.24.11110. PMC 53083 . PMID 1722319.
Smith BL, Agre P (1991). "Erythrocyte Mr 28,000 transmembrane protein exists as a multisubunit oligomer similar to channel proteins". J. Biol. Chem. 266 (10): 6407–15. PMID 2007592.
Denker BM, Smith BL, Kuhajda FP, Agre P (1988). "Identification, purification, and partial characterization of a novel Mr 28,000 integral membrane protein from erythrocytes and renal tubules". J. Biol. Chem. 263 (30): 15634–42. PMID 3049610.
Zelinski T, Kaita H, Lewis M, Coghlan G, Philipps S, Belcher E, McAlpine PJ, Coopland G, Wong P (1988). "The Colton blood group locus. A linkage analysis". Transfusion. 28 (5): 435–8. doi:10.1046/j.1537-2995.1988.28588337331.x. PMID 3166547.
Preston GM, Jung JS, Guggino WB, Agre P (1994). "Membrane topology of aquaporin CHIP. Analysis of functional epitope-scanning mutants by vectorial proteolysis". J. Biol. Chem. 269 (3): 1668–73. PMID 7507481.
Skach WR, Shi LB, Calayag MC, Frigeri A, Lingappa VR, Verkman AS (1994). "Biogenesis and transmembrane topology of the CHIP28 water channel at the endoplasmic reticulum". J. Cell Biol. 125 (4): 803–15. doi:10.1083/jcb.125.4.803. PMC 2120064 . PMID 7514605.
Li X, Yu H, Koide SS (1994). "The water channel gene in human uterus". Biochem. Mol. Biol. Int. 32 (2): 371–7. PMID 7517253.
Walz T, Smith BL, Agre P, Engel A (1994). "The three-dimensional structure of human erythrocyte aquaporin CHIP". EMBO J. 13 (13): 2985–93. PMC 395186 . PMID 7518771.
Preston GM, Smith BL, Zeidel ML, Moulds JJ, Agre P (1994). "Mutations in aquaporin-1 in phenotypically normal humans without functional CHIP water channels". Science. 265 (5178): 1585–7. doi:10.1126/science.7521540. PMID 7521540.
Smith BL, Preston GM, Spring FA, Anstee DJ, Agre P (1994). "Human red cell aquaporin CHIP. I. Molecular characterization of ABH and Colton blood group antigens". J. Clin. Invest. 94 (3): 1043–9. doi:10.1172/JCI117418. PMC 295159 . PMID 7521882.
van Hoek AN, Wiener MC, Verbavatz JM, Brown D, Lipniunas PH, Townsend RR, Verkman AS (1995). "Purification and structure-function analysis of native, PNGase F-treated, and endo-beta-galactosidase-treated CHIP28 water channels". Biochemistry. 34 (7): 2212–9. doi:10.1021/bi00007a015. PMID 7532004.
Keen TJ, Inglehearn CF, Patel RJ, Green ED, Peluso DC, Bhattacharya SS (1995). "Localization of the aquaporin 1 (AQP1) gene within a YAC contig containing the polymorphic markers D7S632 and D7S526". Genomics. 25 (2): 599–600. doi:10.1016/0888-7543(95)80070-3. PMID 7540589.