Kurkumin

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Bentuk keton dari kurkumin

Kurkumin (bahasa Inggris: diferuloylmethane adalah senyawa aktif yang ditemukan pada kunir, berupa polifenol dengan rumus kimia C21H20O6. Kurkumin memiliki dua bentuk tautomer: keton dan enol. Struktur keton lebih dominan dalam bentuk padat, sedangkan struktur enol ditemukan dalam bentuk cairan. Kurkumin merupakan senyawa yang berinteraksi dengan asam borat menghasilkan senyawa berwarna merah yang disebut rososiania.

Senyawa turunan kurkumin disebut kurkuminoid, yang hanya terdapat dua macam, yaitu desmetoksikurkumin dan bis-desmetoksikurkumin, sedangkan in vivo, kurkumin akan berubah menjadi senyawa metabolit berupa dihidrokurkumin atau tetrahidrokurkumin sebelum kemudian dikonversi menjadi senyawa konjugasi monoglusuronida.[1]

Kurkumin dikenal karena sifat antitumor dan antioksidan yang dimilikinya, selain banyak kegunaan medis seperti;

selain itu kurkumin juga:

Defisiensi COX dapat mengakibatkan sindrom Leigh, SCO2 (hypertrophic cardiomyopathy), SCO1 (gagal hati, koma ketoasidosis), and COX10 (encephalopathy, tubulopathy).[22]

Rujukan[sunting | sunting sumber]

  1. ^ (Inggris)"Biotransformation of curcumin through reduction and glucuronidation in mice". Institute of Biochemistry, College of Medicine, National Taiwan University; Pan MH, Huang TM, Lin JK. Diakses 2011-08-23. 
  2. ^ (Inggris)"Curcumin Exerts Neuroprotective Effects Against Homocysteine Intracerebroventricular Injection-Induced Cognitive Impairment and Oxidative Stress in Rat Brain.". Neuroscience Research Center; Ataie A, Sabetkasaei M, Haghparast A, Moghaddam AH, Ataee R, Moghaddam SN. Diakses 2010-06-30. 
  3. ^ (Inggris)"Curcumin attenuates vascular inflammation and cerebral vasospasm after subarachnoid hemorrhage in mice.". Department of Neurosurgery, Medical College of Georgia; Wakade C, King MD, Laird MD, Alleyne CH Jr, Dhandapani KM. Diakses 2010-06-30. 
  4. ^ (Inggris)"Dietary curcumin supplementation counteracts reduction in levels of molecules involved in energy homeostasis after brain trauma". Department of Physiological Science, UCLA; Sharma S, Zhuang Y, Ying Z, Wu A, Gomez-Pinilla F. Diakses 2010-07-04. 
  5. ^ (Inggris)"Curcumin inhibits formation of amyloid beta oligomers and fibrils, binds plaques, and reduces amyloid in vivo". Department of Medicine, UCLA; Curcumin inhibits formation of amyloid beta oligomers and fibrils, binds plaques, and reduces amyloid in vivo. Diakses 2010-06-27. 
  6. ^ (Inggris)"Inhibitory effect of curcuminoids on acetylcholinesterase activity and attenuation of scopolamine-induced amnesia may explain medicinal use of turmeric in Alzheimer's disease". Department of Biological and Biomedical Sciences, The Aga Khan University Medical College; Ahmed T, Gilani AH. Diakses 2010-06-27. 
  7. ^ (Inggris)"Optimized turmeric extracts have potent anti-amyloidogenic effects". Center for Excellence in Aging and Brain Repair, Department of Neurosurgery, University of South Florida College of Medicine; Shytle RD, Bickford PC, Rezai-zadeh K, Hou L, Zeng J, Tan J, Sanberg PR, Sanberg CD, Roschek B Jr, Fink RC, Alberte RS. Diakses 2010-06-27. 
  8. ^ (Inggris)"Immune defects in Alzheimer's disease: new medications development". Human BioMolecular Research Institute, San Diego; Cashman JR, Ghirmai S, Abel KJ, Fiala M. Diakses 2010-06-27. 
  9. ^ (Inggris)"Potential response to curcumin in infantile hemangioendothelioma of the liver.". University of Oklahoma Health Sciences Center; Hassell LA, Roanh LD. Diakses 2010-06-30. 
  10. ^ (Inggris)"[Anticancer activities of curcumin on human hepatocarcinoma cell line Sk-hep-1]". Guangdong Pharmaceutical University; Wang W, Zhang B, Chen H, Zhang L. Diakses 2010-06-30. 
  11. ^ (Inggris)"Curcumin inhibits hepatitis B virus via down-regulation of the metabolic coactivator PGC-1alpha.". The Institute of Gastroenterology and Liver Disease; Rechtman MM, Har-Noy O, Bar-Yishay I, Fishman S, Adamovich Y, Shaul Y, Halpern Z, Shlomai A. Diakses 2010-06-30. 
  12. ^ (Inggris)"Novel role of curcumin in the prevention of cytokine-induced islet death in vitro and diabetogenesis in vivo". Tissue Engineering and Banking Laboratory, National Centre for Cell Science; Kanitkar M, Gokhale K, Galande S, Bhonde RR. Diakses 2010-06-30. 
  13. ^ (Inggris)"Induction of antioxidant enzymes by curcumin and its analogues in human islets: implications in transplantation". Diabetes Institute for Immunology and Transplantation, University of Minnesota; Balamurugan AN, Akhov L, Selvaraj G, Pugazhenthi S. Diakses 2010-06-30. 
  14. ^ (Inggris)"[The study of insulin resistance and leptin resistance on the model of simplicity obesity rats by curcumin]". Department of Public Health, Xi'an Jiaotong University School of Medicine; Yu Y, Hu SK, Yan H. Diakses 2010-06-30. 
  15. ^ (Inggris)"Curcumin protects Leydig cells of mice from damage induced by chronic alcohol administration". Department of Human Morphology and Applied Biology. Faculty of Medicine and Surgery, University of Pisa; Giannessi F, Giambelluca MA, Grasso L, Scavuzzo MC, Ruffoli R. Diakses 2010-06-30. 
  16. ^ (Inggris)"Curcumin and resveratrol inhibit nuclear factor-kappaB-mediated cytokine expression in adipocytes". Department of Biochemistry and Molecular Biology, University of New Mexico, School of Medicine; Gonzales AM, Orlando RA. Diakses 2010-07-04. 
  17. ^ (Inggris)"Role of pro-oxidants and antioxidants in the anti-inflammatory and apoptotic effects of curcumin (diferuloylmethane).". Cytokine Research Laboratory, Department of Experimental Therapeutics, Box 143, The University of Texas M. D. Anderson Cancer Center; Sandur SK, Ichikawa H, Pandey MK, Kunnumakkara AB, Sung B, Sethi G, Aggarwal BB. Diakses 2010-07-04. 
  18. ^ (Inggris)"COX-2 and PGE2 signaling is essential for the regulation of IDO expression by curcumin in murine bone marrow-derived dendritic cells". Department of Microbiology and Immunology and National Research Laboratory of Dendritic Cell Differentiation & Regulation, School of Medicine, Pusan National University; Jung ID, Jeong YI, Lee CM, Noh KT, Jeong SK, Chun SH, Choi OH, Park WS, Han J, Shin YK, Kim HW, Yun CH, Park YM. Diakses 2010-07-04. 
  19. ^ (Inggris)"Curcumin inhibits VEGF-mediated angiogenesis in human intestinal microvascular endothelial cells through COX-2 and MAPK inhibition". Department of Surgery, Medical College of Wisconsin; Binion DG, Otterson MF, Rafiee P. Diakses 2010-07-04. 
  20. ^ (Inggris)"Comparison of Anti-inflammatory Activities of Six Curcuma Rhizomes: A Possible Curcuminoid-independent Pathway Mediated by Curcuma phaeocaulis Extract.". Tohda C, Nakayama N, Hatanaka F, Komatsu K. Diakses 2010-07-04. 
  21. ^ (Inggris)"Control of the growth of human breast cancer cells in culture by manipulation of arachidonate metabolism.". Walter Reed Army Institute of Research; Hammamieh R, Sumaida D, Zhang X, Das R, Jett M. Diakses 2010-07-04. 
  22. ^ (Inggris)"A missense mutation of cytochrome oxidase subunit II causes defective assembly and myopathy.". University Department of Clinical Neurosciences, Royal Free and University College Medical School; Rahman S, Taanman JW, Cooper JM, Nelson I, Hargreaves I, Meunier B, Hanna MG, García JJ, Capaldi RA, Lake BD, Leonard JV, Schapira AH. Diakses 2010-07-04. 

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