SHANK1

SHANK1
Pengidentifikasi
Alias	SHANK1, SPANK-1, SSTRIP, synamon, SH3 and multiple ankyrin repeat domains 1
ID eksternal	OMIM: 604999 MGI: 3613677 HomoloGene: 22949 GeneCards: SHANK1
Lokasi gen (Tikus)
Kr.	Kromosom 7 (tikus)
Akhir	44,009,996 bp
Ontologi gen
Fungsi molekuler	• somatostatin receptor binding; • SH3 domain binding; • ankyrin repeat binding; • scaffold protein binding; • protein C-terminus binding; • GO:0001948, GO:0016582 Ikatan protein plasma; • synaptic receptor adaptor activity; • pengikatan protein identik; • ionotropic glutamate receptor binding; • signaling receptor complex adaptor activity; • GO:0032403 protein-containing complex binding;
Komponen seluler	• sitoplasma; • postsynaptic membrane; • membran; • dendritic spine; • sinapsis; • excitatory synapse; • intracellular anatomical structure; • NMDA selective glutamate receptor complex; • Sambungan sel; • Dendrit; • neuron projection; • ionotropic glutamate receptor complex; • GO:0097483, GO:0097481 postsynaptic density; • sitosol; • Membran sel; • Schaffer collateral - CA1 synapse; • glutamatergic synapse; • neuron spine;
Proses biologis	• Diferensiasi sel; • olfactory behavior; • associative learning; • neuromuscular process controlling balance; • negative regulation of actin filament bundle assembly; • positive regulation of dendritic spine development; • perkembangan sistem saraf; • regulation of AMPA receptor activity; • dendritic spine morphogenesis; • vocalization behavior; • adult behavior; • long-term memory; • synapse maturation; • positive regulation of excitatory postsynaptic potential; • perilaku sosial; • kebiasaan; • determination of affect; • righting reflex; • protein localization to synapse; • GO:0034622 protein-containing complex assembly; • postsynapse organization; • Sinaptogenesis; • brain morphogenesis; • synaptic assembly at neuromuscular junction; • positive regulation of synaptic transmission, glutamatergic; • long-term potentiation; • postsynaptic density assembly;
	Sumber:Amigo / QuickGO
Ortolog
	50944
	243961
	ENSG00000161681
	ENSMUSG00000038738
	Q9Y566
	D3YZU1
	NM_016148
	NM_001034115
	NP_057232
	NP_001029287
	Wikidata
Lihat/Sunting Manusia	Lihat/Sunting Tikus

SH3 dan beberapa ankyrin ulangi domain protein 1 adalah protein yang pada manusia dikodekan oleh gen SHANK1.^[4]^[5]

Interaksi[sunting | sunting sumber]

SHANK1 telah diketahui berinteraksi dengan:

ARHGEF7,^[6]
BAIAP2,^[7]
DNM2,^[8]
SPTAN1,^[9] dan
Reseptor Somatostatin 2.

Referensi[sunting | sunting sumber]

^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000038738 - Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Zitzer H, Hönck HH, Bächner D, Richter D, Kreienkamp HJ (January 2000). "Somatostatin receptor interacting protein defines a novel family of multidomain proteins present in human and rodent brain". J Biol Chem. 274 (46): 32997–3001. doi:10.1074/jbc.274.46.32997. PMID 10551867.
^ "Entrez Gene: SHANK1 SH3 and multiple ankyrin repeat domains 1".
^ Park E, Na M, Choi J, Kim S, Lee JR, Yoon J, Park D, Sheng M, Kim E (May 2003). "The Shank family of postsynaptic density proteins interacts with and promotes synaptic accumulation of the beta PIX guanine nucleotide exchange factor for Rac1 and Cdc42". J. Biol. Chem. 278 (21): 19220–9. doi:10.1074/jbc.M301052200. PMID 12626503.
^ Soltau M, Richter D, Kreienkamp HJ (Dec 2002). "The insulin receptor substrate IRSp53 links postsynaptic shank1 to the small G-protein cdc42". Mol. Cell. Neurosci. 21 (4): 575–83. doi:10.1006/mcne.2002.1201. PMID 12504591.
^ Okamoto PM, Gamby C, Wells D, Fallon J, Vallee RB (Dec 2001). "Dynamin isoform-specific interaction with the shank/ProSAP scaffolding proteins of the postsynaptic density and actin cytoskeleton". J. Biol. Chem. 276 (51): 48458–65. doi:10.1074/jbc.M104927200. PMC 2715172 . PMID 11583995.
^ Böckers TM, Mameza MG, Kreutz MR, Bockmann J, Weise C, Buck F, Richter D, Gundelfinger ED, Kreienkamp HJ (October 2001). "Synaptic scaffolding proteins in rat brain. Ankyrin repeats of the multidomain Shank protein family interact with the cytoskeletal protein alpha-fodrin". J. Biol. Chem. 276 (43): 40104–12. doi:10.1074/jbc.M102454200. PMID 11509555.

[refGRCm38Ensembl-1] GRCm38: Ensembl release 89: ENSMUSG00000038738 - Ensembl, May 2017

[2] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[3] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid10551867-4] Zitzer H, Hönck HH, Bächner D, Richter D, Kreienkamp HJ (January 2000). "Somatostatin receptor interacting protein defines a novel family of multidomain proteins present in human and rodent brain". J Biol Chem. 274 (46): 32997–3001. doi:10.1074/jbc.274.46.32997. PMID 10551867.

[entrez-5] "Entrez Gene: SHANK1 SH3 and multiple ankyrin repeat domains 1".

[pmid12626503-6] Park E, Na M, Choi J, Kim S, Lee JR, Yoon J, Park D, Sheng M, Kim E (May 2003). "The Shank family of postsynaptic density proteins interacts with and promotes synaptic accumulation of the beta PIX guanine nucleotide exchange factor for Rac1 and Cdc42". J. Biol. Chem. 278 (21): 19220–9. doi:10.1074/jbc.M301052200. PMID 12626503.

[pmid12504591-7] Soltau M, Richter D, Kreienkamp HJ (Dec 2002). "The insulin receptor substrate IRSp53 links postsynaptic shank1 to the small G-protein cdc42". Mol. Cell. Neurosci. 21 (4): 575–83. doi:10.1006/mcne.2002.1201. PMID 12504591.

[pmid11583995-8] Okamoto PM, Gamby C, Wells D, Fallon J, Vallee RB (Dec 2001). "Dynamin isoform-specific interaction with the shank/ProSAP scaffolding proteins of the postsynaptic density and actin cytoskeleton". J. Biol. Chem. 276 (51): 48458–65. doi:10.1074/jbc.M104927200. PMC 2715172 . PMID 11583995.

[pmid11509555-9] Böckers TM, Mameza MG, Kreutz MR, Bockmann J, Weise C, Buck F, Richter D, Gundelfinger ED, Kreienkamp HJ (October 2001). "Synaptic scaffolding proteins in rat brain. Ankyrin repeats of the multidomain Shank protein family interact with the cytoskeletal protein alpha-fodrin". J. Biol. Chem. 276 (43): 40104–12. doi:10.1074/jbc.M102454200. PMID 11509555.

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