S1PR1

S1PR1
Struktur yang tersedia
PDB	Pencarian Ortolog: PDBe RCSB
Daftar kode id PDB
	3V2W, 3V2Y
Pengidentifikasi
Alias	S1PR1, CD363, CHEDG1, D1S3362, ECGF1, EDG-1, EDG1, S1P1, sphingosine-1-phosphate receptor 1
ID eksternal	OMIM: 601974 MGI: 1096355 HomoloGene: 1071 GeneCards: S1PR1
Lokasi gen (Tikus)
Kr.	Kromosom 3 (tikus)
Akhir	115,508,721 bp
Pola ekspresi RNA
	Referensi data ekspresi selengkapnya
Ontologi gen
Fungsi molekuler	• sphingolipid binding; • sphingosine-1-phosphate receptor activity; • G protein-coupled receptor activity; • signal transducer activity; • G protein-coupled receptor binding; • GO:0001948, GO:0016582 Ikatan protein plasma;
Komponen seluler	• komponen integral membran; • endosom; • membran; • intrinsic component of plasma membrane; • Membran sel; • membrane raft; • external side of plasma membrane; • nucleoplasm; • intracellular membrane-bounded organelle;
Proses biologis	• actin cytoskeleton reorganization; • T cell migration; • G protein-coupled receptor signaling pathway; • heart trabecula morphogenesis; • positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G protein-coupled signaling pathway; • adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway; • sphingosine-1-phosphate receptor signaling pathway; • positive regulation of cell migration; • regulation of bone mineralization; • transmission of nerve impulse; • chemotaxis; • positive regulation of positive chemotaxis; • GO:0032320, GO:0032321, GO:0032855, GO:0043089, GO:0032854 positive regulation of GTPase activity; • brain development; • regulation of cell adhesion; • Adhesi sel; • Angiogenesis; • neuron differentiation; • positive regulation of cell population proliferation; • endothelial cell differentiation; • negative regulation of stress fiber assembly; • regulation of bone resorption; • Migrasi sel; • GO:0072468 signal transduction; • lamellipodium assembly; • GO:0003257, GO:0010735, GO:1901228, GO:1900622, GO:1904488 positive regulation of transcription by RNA polymerase II; • cardiac muscle tissue growth involved in heart morphogenesis; • positive regulation of smooth muscle cell proliferation; • blood vessel maturation; • leukocyte chemotaxis; • cytokine-mediated signaling pathway;
	Sumber:Amigo / QuickGO
Ortolog
	1901
	13609
	ENSG00000170989
	ENSMUSG00000045092
	P21453
	O08530
	NM_001400; NM_001320730
	NM_007901
	NP_001307659; NP_001391
	NP_031927
	Wikidata
Lihat/Sunting Manusia	Lihat/Sunting Tikus

Sphingosine-1-fosfat reseptor 1 (S1P reseptor 1 atau S1P1), juga dikenal sebagai endotel diferensiasi gen 1 (EDG1) adalah protein yang pada manusia dikodekan oleh gen S1PR1. S1PR1 adalah GReseptor terhubung-protein G yang mengikat sinyal molekul bioaktif sphingosine 1-fosfat (S1P). S1PR1 merupakan anggota subfamili sphingosine-1-fosfat reseptor yang terdiri dari lima anggota (S1PR1-5). S1PR1 awalnya diidentifikasi sebagai transkrip yang melimpah di sel endotel^[4] dan memiliki peran penting dalam mengatur struktur sel endotel sitoskeleton, migrasi, pembentukan jaringan kapiler dan pematangan pembuluh darah.^[5]^[6] selain itu, sinyal S1PR1 penting dalam regulasi pematangan, migrasi dan penyaluran limfosit,.^[7]^[8]

Referensi[sunting | sunting sumber]

^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000045092 - Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "An abundant transcript induced in differentiating human endothelial cells encodes a polypeptide with structural similarities to G-protein-coupled receptors". J. Biol. Chem. 265 (16): 9308–13. June 1990. PMID 2160972.
^ "Sphingosine-1-phosphate as a ligand for the G protein-coupled receptor EDG-1". Science. 279 (5356): 1552–5. March 1998. doi:10.1126/science.279.5356.1552. PMID 9488656.
^ "Ligand-induced trafficking of the sphingosine-1-phosphate receptor EDG-1". Mol. Biol. Cell. 10 (4): 1179–90. April 1999. doi:10.1091/mbc.10.4.1179. PMC 25247 . PMID 10198065.
^ "Expression of the sphingosine 1-phosphate receptor, S1P1, on T-cells controls thymic emigration". J. Biol. Chem. 279 (15): 15396–401. April 2004. doi:10.1074/jbc.M314291200. PMID 14732704.
^ "Lymphocyte egress from thymus and peripheral lymphoid organs is dependent on S1P receptor 1". Nature. 427 (6972): 355–60. January 2004. doi:10.1038/nature02284. PMID 14737169.

[refGRCm38Ensembl-1] GRCm38: Ensembl release 89: ENSMUSG00000045092 - Ensembl, May 2017

[2] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[3] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[Hla_1990-4] "An abundant transcript induced in differentiating human endothelial cells encodes a polypeptide with structural similarities to G-protein-coupled receptors". J. Biol. Chem. 265 (16): 9308–13. June 1990. PMID 2160972.

[Lee_1998-5] "Sphingosine-1-phosphate as a ligand for the G protein-coupled receptor EDG-1". Science. 279 (5356): 1552–5. March 1998. doi:10.1126/science.279.5356.1552. PMID 9488656.

[Liu_1999-6] "Ligand-induced trafficking of the sphingosine-1-phosphate receptor EDG-1". Mol. Biol. Cell. 10 (4): 1179–90. April 1999. doi:10.1091/mbc.10.4.1179. PMC 25247 . PMID 10198065.

[Allende_2004-7] "Expression of the sphingosine 1-phosphate receptor, S1P1, on T-cells controls thymic emigration". J. Biol. Chem. 279 (15): 15396–401. April 2004. doi:10.1074/jbc.M314291200. PMID 14732704.

[Matloubian_2004-8] "Lymphocyte egress from thymus and peripheral lymphoid organs is dependent on S1P receptor 1". Nature. 427 (6972): 355–60. January 2004. doi:10.1038/nature02284. PMID 14737169.

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