p73

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p73 (bahasa Inggris: tumor protein 73) adalah faktor transkripsi dengan berkas genetik TP73,[1]

Defisiensi genetik pada protein ini diketahui dapat menimbulkan berbagai neuroblastoma dan berbaga kanker lain. Peredaman transkripsi genetik dengan proses metilasi DNA pada manusia mengakibatkan berbagai jenis leukemia dan limfoma.[2]

Ekspresi genetik p73 dapat ditingkatkan dengan asam askorbat.[3]

Rujukan[sunting | sunting sumber]

  1. ^ (Inggris)"TP73 tumor protein p73 [ Homo sapiens ]". Entrez Gene. Diakses 2010-12-12. 
  2. ^ (Inggris)"Targeted Deletion of p73 in Mice Reveals Its Role in T Cell Development and Lymphomagenesis". Department of Pathology, State University of New York at Stony Brook, Department of Medicine, Albert Einstein College of Medicine, Department of Biochemistry and Center of Excellence in Bioinformatics and Life Sciences, University at Buffalo, State University of New York, Roswell Park Cancer Institute, Roswell Park Cancer Institute; Alice Nemajerova, Gustavo Palacios, Norma J. Nowak, Sei-ichi Matsui, dan Oleksi Petrenko. Diakses 2010-12-12. "Transcriptional silencing of the p73 gene through methylation has been demonstrated in human leukemias and lymphomas." 
  3. ^ (Inggris)"Ascorbate up-regulates MLH1 (Mut L homologue-1) and p73: implications for the cellular response to DNA damage". Biochemistry Laboratory, IDI-IRCCS, c/o Department of Experimental Medicine & Biochemical Sciences, University of Rome Tor Vergata, Laboratory of Gene Expression, Fondazione A. Cesalpino, University of Rome La Sapienza, Department of Biology and the Cancer Center, University of California; M. Valeria CATANI, Antonio COSTANZO, Isabella SAVINI, Massimo LEVRERO, Vincenzo DE LAURENZI, Jean Y. J. WANG, Gerry MELINOŒdan Luciana AVIGLIANO. Diakses 2010-12-12.