Glutamin sintetase

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glutamate—ammonia ligase
Active site between two monomers of glutamine synthetase from Salmonella typhimurium. Cation binding sites are yellow and orange; ADP is pink; phosphinothricin is blue.[1]
Pengidentifikasi
Nomor EC6.3.1.2
Nomor CAS9023-70-5
Basis data
IntEnztinjauan IntEnz
BRENDAentri BRENDA
ExPASytinjauan NiceZyme
KEGGentri KEGG
MetaCycjalur metabolik
PRIAMprofil
Struktur PDBRCSB PDB PDBe PDBsum
Ontologi GenAmiGO / EGO
Glutamine synthetase,
beta-Grasp domain
Identifikasi
SimbolGln-synt_N
PfamPF03951
InterProIPR008147
PROSITEPDOC00162
SCOP2gls
SUPERFAMILY2gls
Glutamine synthetase,
catalytic domain
12-subunit enzyme glutamine synthetase from Salmonella typhimurium.[2]
Identifikasi
SimbolGln-synt_C
PfamPF00120
Klan PfamCL0286
InterProIPR008146
PROSITEPDOC00162
SCOP2gls
SUPERFAMILY2gls
glutamate-ammonia ligase (glutamine synthetase)
Pengidentifikasi
SimbolGLUL
Simbol alternatifGLNS
Gen NCBI2752
HGNC4341
OMIM138290
PDB2qc8
RefSeqNM_002065
UniProtP15104
Data lain
Nomor EC6.3.1.2
LokusChr. 1 q31

Glutamin sintetase (GS) (EC 6.3.1.2)[3] adalah enzim yang memainkan peran penting dalam metabolisme nitrogen dengan mengkatalisis kondensasi glutamat dan amonia untuk membentuk glutamin:

Glutamat + ATP + NH3 → Glutamin + ADP + fosfat

Glutamine Synthetase reaction.
Glutamine Synthetase Catalyzed Reaction.

Referensi[sunting | sunting sumber]

  1. ^ PDB: 1FPY​; Gill HS, Eisenberg D (February 2001). "The crystal structure of phosphinothricin in the active site of glutamine synthetase illuminates the mechanism of enzymatic inhibition". Biochemistry. 40 (7): 1903–12. doi:10.1021/bi002438h. PMID 11329256. 
  2. ^ PDB: 2GLS​; Yamashita MM, Almassy RJ, Janson CA, Cascio D, Eisenberg D (October 1989). "Refined atomic model of glutamine synthetase at 3.5 A resolution". J. Biol. Chem. 264 (30): 17681–90. PMID 2572586. 
  3. ^ Eisenberg D, Almassy RJ, Janson CA, Chapman MS, Suh SW, Cascio D, Smith WW (1987). "Some evolutionary relationships of the primary biological catalysts glutamine synthetase and RuBisCO". Cold Spring Harb. Symp. Quant. Biol. 52: 483–90. doi:10.1101/sqb.1987.052.01.055. PMID 2900091. 

Pranala luar[sunting | sunting sumber]

Templat:Ligase Templat:Amino acid metabolism enzymes