DPYSL2

DPYSL2
Struktur yang tersedia
PDB	Pencarian Ortolog: PDBe RCSB
Daftar kode id PDB
	2GSE, 2VM8
Pengidentifikasi
Alias	DPYSL2, CRMP-2, CRMP2, DHPRP2, DRP-2, DRP2, N2A3, ULIP-2, ULIP2, dihydropyrimidinase like 2
ID eksternal	OMIM: 602463 MGI: 1349763 HomoloGene: 74392 GeneCards: DPYSL2
Lokasi gen (Manusia)
Kr.	Kromosom 8 (manusia)
Akhir	26,658,178 bp
Lokasi gen (Tikus)
Kr.	Kromosom 14 (tikus)
Akhir	67,106,137 bp
Pola ekspresi RNA
	Referensi data ekspresi selengkapnya
Ontologi gen
Fungsi molekuler	• microtubule binding; • dihydropyrimidinase activity; • GO:0001948, GO:0016582 Ikatan protein plasma; • hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds; • hydrolase activity; • pengikatan protein identik;
Komponen seluler	• sitoplasma; • sitosol; • membran; • extracellular exosome; • Mikrotubulus; • Sitoskeleton; • Membran sel;
Proses biologis	• regulation of neuron differentiation; • Diferensiasi sel; • Endositosis; • regulation of axon extension; • perkembangan sistem saraf; • multicellular organism development; • brain development; • cytoskeleton organization; • nucleobase-containing compound metabolic process; • GO:0072468 signal transduction; • axon guidance; • pyrimidine nucleobase catabolic process;
	Sumber:Amigo / QuickGO
Ortolog
	1808
	12934
	ENSG00000092964
	ENSMUSG00000022048
	Q16555
	O08553
	NM_001386; NM_001197293; NM_001244604
	NM_009955; NM_001378767
	NP_001184222; NP_001231533; NP_001377
	NP_034085; NP_001365696
	Wikidata
Lihat/Sunting Manusia	Lihat/Sunting Tikus

Protein terkait dihydropyrimidinase 2 adalah enzim yang pada manusia dikodekan oleh gen DPYSL2.^[5]^[6]

Interaksi[sunting | sunting sumber]

DPYSL2 telah terbukti memiliki interaksi dengan CRMP1,^[7] alpha 1^[8] dan NUMB.

Referensi[sunting | sunting sumber]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000092964 - Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000022048 - Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Hamajima N, Matsuda K, Sakata S, Tamaki N, Sasaki M, Nonaka M (Jan 1997). "A novel gene family defined by human dihydropyrimidinase and three related proteins with differential tissue distribution". Gene. 180 (1–2): 157–63. doi:10.1016/S0378-1119(96)00445-3. PMID 8973361.
^ "Entrez Gene: DPYSL2 dihydropyrimidinase-like 2".
^ Leung, Thomas; Ng Yvonne; Cheong Albert; Ng Chong Han; Tan Ivan; Hall Christine; Lim Louis (Dec 2002). "p80 ROKalpha binding protein is a novel splice variant of CRMP-1 which associates with CRMP-2 and modulates RhoA-induced neuronal morphology". FEBS Lett. Netherlands. 532 (3): 445–9. doi:10.1016/S0014-5793(02)03736-5. ISSN 0014-5793. PMID 12482610.
^ Nishimura, Takashi; Fukata Yuko; Kato Katsuhiro; Yamaguchi Tomoya; Matsuura Yoshiharu; Kamiguchi Hiroyuki; Kaibuchi Kozo (Sep 2003). "CRMP-2 regulates polarized Numb-mediated endocytosis for axon growth". Nat. Cell Biol. England. 5 (9): 819–26. doi:10.1038/ncb1039. ISSN 1465-7392. PMID 12942088.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000092964 - Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000022048 - Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid8973361-5] Hamajima N, Matsuda K, Sakata S, Tamaki N, Sasaki M, Nonaka M (Jan 1997). "A novel gene family defined by human dihydropyrimidinase and three related proteins with differential tissue distribution". Gene. 180 (1–2): 157–63. doi:10.1016/S0378-1119(96)00445-3. PMID 8973361.

[entrez-6] "Entrez Gene: DPYSL2 dihydropyrimidinase-like 2".

[pmid12482610-7] Leung, Thomas; Ng Yvonne; Cheong Albert; Ng Chong Han; Tan Ivan; Hall Christine; Lim Louis (Dec 2002). "p80 ROKalpha binding protein is a novel splice variant of CRMP-1 which associates with CRMP-2 and modulates RhoA-induced neuronal morphology". FEBS Lett. Netherlands. 532 (3): 445–9. doi:10.1016/S0014-5793(02)03736-5. ISSN 0014-5793. PMID 12482610.

[pmid12942088-8] Nishimura, Takashi; Fukata Yuko; Kato Katsuhiro; Yamaguchi Tomoya; Matsuura Yoshiharu; Kamiguchi Hiroyuki; Kaibuchi Kozo (Sep 2003). "CRMP-2 regulates polarized Numb-mediated endocytosis for axon growth". Nat. Cell Biol. England. 5 (9): 819–26. doi:10.1038/ncb1039. ISSN 1465-7392. PMID 12942088.

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