ACBD3

ACBD3
Struktur yang tersedia
PDB	Pencarian Ortolog: PDBe RCSB
Daftar kode id PDB
	2N72
Pengidentifikasi
Alias	ACBD3, GCP60, GOCAP1, GOLPH1, PAP7, acyl-CoA binding domain containing 3
ID eksternal	OMIM: 606809 MGI: 2181074 HomoloGene: 11227 GeneCards: ACBD3
Lokasi gen (Tikus)
Kr.	Kromosom 1 (tikus)
Akhir	180,581,769 bp
Pola ekspresi RNA
	Referensi data ekspresi selengkapnya
Ontologi gen
Fungsi molekuler	• protein kinase A regulatory subunit binding; • GO:0001948, GO:0016582 Ikatan protein plasma; • fatty-acyl-CoA binding;
Komponen seluler	• komponen integral membran; • badan Golgi; • membran; • mitokondria; • Golgi membrane;
Proses biologis	• steroid biosynthetic process; • metabolisme lipid; • GO:0015915 transpor;
	Sumber:Amigo / QuickGO
Ortolog
	64746
	170760
	ENSG00000182827
	ENSMUSG00000026499
	Q9H3P7
	Q8BMP6
	NM_022735
	NM_133225
	NP_073572; NP_073572.2
	NP_573488
	Wikidata
Lihat/Sunting Manusia	Lihat/Sunting Tikus

Golgi resident protein GCP60 adalah protein yang pada manusia dikodekan oleh gen ACBD3.^[4]

Fungsi[sunting | sunting sumber]

Badan Golgi memainkan peran kunci dalam pemilahan dan modifikasi protein yang diekspor dari retikulum endoplasma. ACBD3 berperan menjaga struktur Golgi dan berinteraksi dengan giantin, yang mempengaruhi pengangkutan protein.^[5] Protein yang dikodekan oleh gen ini terlibat dalam pemeliharaan struktur dan fungsi Golgi melalui interaksinya dengan protein raksasa membran integral. Gen ini mungkin juga terlibat dalam regulasi hormonal pembentukan steroid.^[4]

Interaksi[sunting | sunting sumber]

ACBD3 telah terbukti berinteraksi dengan GOLGB1.^[6]

Referensi[sunting | sunting sumber]

^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000026499 - Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ ^a ^b "Entrez Gene: ACBD3 acyl-Coenzyme A binding domain containing 3".
^ "ACBD3 - Golgi resident protein GCP60 - Homo sapiens (Human) - ACBD3 gene & protein".
^ Sohda M, Misumi Y, Yamamoto A, Yano A, Nakamura N, Ikehara Y (November 2001). "Identification and characterization of a novel Golgi protein, GCP60, that interacts with the integral membrane protein giantin". J. Biol. Chem. 276 (48): 45298–306. doi:10.1074/jbc.M108961200 . PMID 11590181.

Pranala luar[sunting | sunting sumber]

Lokasi genom ACBD3 manusia dan halaman rincian gen ACBD3 dalam UCSC Genome Browser.

Bacaan lanjutan[sunting | sunting sumber]

Sohda M, Misumi Y, Yamamoto A, Yano A, Nakamura N, Ikehara Y (2002). "Identification and characterization of a novel Golgi protein, GCP60, that interacts with the integral membrane protein giantin". J. Biol. Chem. 276 (48): 45298–306. doi:10.1074/jbc.M108961200 . PMID 11590181.
Li H, Degenhardt B, Tobin D, Yao ZX, Tasken K, Papadopoulos V (2002). "Identification, localization, and function in steroidogenesis of PAP7: a peripheral-type benzodiazepine receptor- and PKA (RIalpha)-associated protein". Mol. Endocrinol. 15 (12): 2211–28. doi:10.1210/me.15.12.2211. PMID 11731621.
Gevaert K, Goethals M, Martens L, Van Damme J, Staes A, Thomas GR, Vandekerckhove J (2004). "Exploring proteomes and analyzing protein processing by mass spectrometric identification of sorted N-terminal peptides". Nat. Biotechnol. 21 (5): 566–9. doi:10.1038/nbt810. PMID 12665801.
Liu J, Matyakhina L, Han Z, Sandrini F, Bei T, Stratakis CA, Papadopoulos V (2003). "Molecular cloning, chromosomal localization of human peripheral-type benzodiazepine receptor and PKA regulatory subunit type 1A (PRKAR1A)-associated protein PAP7, and studies in PRKAR1A mutant cells and tissues". FASEB J. 17 (9): 1189–91. doi:10.1096/fj.02-1066fje. PMID 12692076.
Colland F, Jacq X, Trouplin V, Mougin C, Groizeleau C, Hamburger A, Meil A, Wojcik J, Legrain P, Gauthier JM (2004). "Functional Proteomics Mapping of a Human Signaling Pathway". Genome Res. 14 (7): 1324–32. doi:10.1101/gr.2334104. PMC 442148 . PMID 15231748.
Sbodio JI, Hicks SW, Simon D, Machamer CE (2006). "GCP60 preferentially interacts with a caspase-generated golgin-160 fragment". J. Biol. Chem. 281 (38): 27924–31. doi:10.1074/jbc.M603276200 . PMID 16870622.
Sbodio JI, Machamer CE (2007). "Identification of a redox-sensitive cysteine in GCP60 that regulates its interaction with golgin-160". J. Biol. Chem. 282 (41): 29874–81. doi:10.1074/jbc.M705794200 . PMID 17711851.

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[refGRCm38Ensembl-1] GRCm38: Ensembl release 89: ENSMUSG00000026499 - Ensembl, May 2017

[2] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[3] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[entrez-4] "Entrez Gene: ACBD3 acyl-Coenzyme A binding domain containing 3".

[5] "ACBD3 - Golgi resident protein GCP60 - Homo sapiens (Human) - ACBD3 gene & protein".

[pmid11590181-6] Sohda M, Misumi Y, Yamamoto A, Yano A, Nakamura N, Ikehara Y (November 2001). "Identification and characterization of a novel Golgi protein, GCP60, that interacts with the integral membrane protein giantin". J. Biol. Chem. 276 (48): 45298–306. doi:10.1074/jbc.M108961200 . PMID 11590181.

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