Reseptor apolipoprotein E 2

Reseptor apolipoprotein E 2 (ApoER2) juga dikenal sebagai low-density lipoprotein receptor-related protein 8 (LRP8), adalah protein yang pada manusia disandikan oleh gen LRP8.^[1]^[2]^[3] ApoER2 adalah reseptor permukaan sel yang merupakan bagian dari keluarga reseptor lipoprotein densitas rendah. Reseptor ini berfungsi dalam transduksi sinyal dan endositosis ligan tertentu. Melalui interaksi dengan salah satu ligannya, reelin, ApoER2 memainkan peran penting dalam migrasi neuron embrionik dan potensiasi jangka panjang pascakelahiran. Reseptor keluarga LDL lainnya, VLDLR, juga berinteraksi dengan reelin, dan kedua reseptor bersama-sama memengaruhi perkembangan dan fungsi otak. Penurunan ekspresi ApoER2 dikaitkan dengan penyakit neurologis tertentu.^[4]

Referensi[sunting | sunting sumber]

^ Kim DH, Iijima H, Goto K, Sakai J, Ishii H, Kim HJ, Suzuki H, Kondo H, Saeki S, Yamamoto T (Jun 1996). "Human apolipoprotein E receptor 2. A novel lipoprotein receptor of the low density lipoprotein receptor family predominantly expressed in brain". J Biol Chem. 271 (14): 8373–80. doi:10.1074/jbc.271.14.8373. PMID 8626535.
^ Kim DH, Magoori K, Inoue TR, Mao CC, Kim HJ, Suzuki H, Fujita T, Endo Y, Saeki S, Yamamoto TT (May 1997). "Exon/intron organization, chromosome localization, alternative splicing, and transcription units of the human apolipoprotein E receptor 2 gene". J Biol Chem. 272 (13): 8498–504. doi:10.1074/jbc.272.13.8498. PMID 9079678.
^ "Entrez Gene: LRP8 low density lipoprotein receptor-related protein 8, apolipoprotein e receptor".
^ Myant NB (February 2010). "Reelin and apolipoprotein E receptor 2 in the embryonic and mature brain: effects of an evolutionary change in the apoER2 gene". Proc. Biol. Sci. 277 (1680): 345–51. doi:10.1098/rspb.2009.1412. PMC 2842643 . PMID 19846452.

[pmid8626535-1] Kim DH, Iijima H, Goto K, Sakai J, Ishii H, Kim HJ, Suzuki H, Kondo H, Saeki S, Yamamoto T (Jun 1996). "Human apolipoprotein E receptor 2. A novel lipoprotein receptor of the low density lipoprotein receptor family predominantly expressed in brain". J Biol Chem. 271 (14): 8373–80. doi:10.1074/jbc.271.14.8373. PMID 8626535.

[pmid9079678-2] Kim DH, Magoori K, Inoue TR, Mao CC, Kim HJ, Suzuki H, Fujita T, Endo Y, Saeki S, Yamamoto TT (May 1997). "Exon/intron organization, chromosome localization, alternative splicing, and transcription units of the human apolipoprotein E receptor 2 gene". J Biol Chem. 272 (13): 8498–504. doi:10.1074/jbc.272.13.8498. PMID 9079678.

[entrez-3] "Entrez Gene: LRP8 low density lipoprotein receptor-related protein 8, apolipoprotein e receptor".

[Myant_2010-4] Myant NB (February 2010). "Reelin and apolipoprotein E receptor 2 in the embryonic and mature brain: effects of an evolutionary change in the apoER2 gene". Proc. Biol. Sci. 277 (1680): 345–51. doi:10.1098/rspb.2009.1412. PMC 2842643 . PMID 19846452.

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