NF-κB: Perbedaan antara revisi
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'''NF-κB''' ({{lang-en|nuclear factor kappa-light-chain-enhancer of activated B cells, nuclear factor-kappaB}}) adalah keluarga [[faktor transkripsi]] yang berperan dalam respon seluler terhadap rangsangan seperti stres, [[sitokina]], [[radikal bebas]], [[logam berat]], [[iradiasi ultraviolet]], [[LDL]] yang teroksidasi, dan bakteri atau virus ([[antigen]]).<ref name="pmid17072321">{{cite journal | vauthors = Gilmore TD | title = Introduction to NF-kappaB: players, pathways, perspectives | journal = Oncogene | volume = 25 | issue = 51 | pages = 6680–4 | date = October 2006 | pmid = 17072321 | doi = 10.1038/sj.onc.1209954 }}</ref><ref name="pmid17303919">{{cite journal | vauthors = Brasier AR | title = The NF-kappaB regulatory network | journal = Cardiovascular Toxicology | volume = 6 | issue = 2 | pages = 111–30 | year = 2006 | pmid = 17303919 | doi = 10.1385/CT:6:2:111 }}</ref><ref name="pmid17183360">{{cite journal | vauthors = Perkins ND | title = Integrating cell-signalling pathways with NF-kappaB and IKK function | journal = Nature Reviews Molecular Cell Biology | volume = 8 | issue = 1 | pages = 49–62 | date = January 2007 | pmid = 17183360 | doi = 10.1038/nrm2083 }}</ref><ref name="pmid10602459">{{cite journal | vauthors = Gilmore TD | title = The Rel/NF-kappaB signal transduction pathway: introduction | journal = Oncogene | volume = 18 | issue = 49 | pages = 6842–4 | date = November 1999 | pmid = 10602459 | doi = 10.1038/sj.onc.1203237 }}</ref><ref name="pmid12795416">{{cite journal | vauthors = Tian B, Brasier AR | title = Identification of a nuclear factor kappa B-dependent gene network | journal = Recent Progress in Hormone Research | volume = 58 | issue = | pages = 95–130 | year = 2003 | pmid = 12795416 | doi = 10.1210/rp.58.1.95 }}</ref> NF-κB memainkan peran kunci dalam mengatur respon imun terhadap infeksi (rantai ringan κ adalah komponen penting [[imunoglobulin]]). Regulasi NF-κB yang salah telah dikaitkan dengan kanker, inflamasi dan [[penyakit autoimun]], [[syok septik]], infeksi virus, dan gangguan sistem imun. NF-κB juga terlibat dalam proses [[plastisitas sinaptik]] dan memori.<ref name="Albensi_2000">{{cite journal | vauthors = Albensi BC, Mattson MP | title = Evidence for the involvement of TNF and NF-kappaB in hippocampal synaptic plasticity | journal = Synapse | volume = 35 | issue = 2 | pages = 151–9 | date = February 2000 | pmid = 10611641 | doi = 10.1002/(SICI)1098-2396(200002)35:2<151::AID-SYN8>3.0.CO;2-P }}</ref><ref name="Meffert_2003">{{cite journal | vauthors = Meffert MK, Chang JM, Wiltgen BJ, Fanselow MS, Baltimore D | title = NF-kappa B functions in synaptic signaling and behavior | journal = Nature Neuroscience | volume = 6 | issue = 10 | pages = 1072–8 | date = October 2003 | pmid = 12947408 | doi = 10.1038/nn1110 }}</ref><ref name="Levenson_2004">{{cite journal | vauthors = Levenson JM, Choi S, Lee SY, Cao YA, Ahn HJ, Worley KC, Pizzi M, Liou HC, Sweatt JD | title = A bioinformatics analysis of memory consolidation reveals involvement of the transcription factor c-rel | journal = The Journal of Neuroscience | volume = 24 | issue = 16 | pages = 3933–43 | date = April 2004 | pmid = 15102909 | doi = 10.1523/JNEUROSCI.5646-03.2004 }}</ref><ref name="Freudenthal_1998">{{cite journal | vauthors = Freudenthal R, Locatelli F, Hermitte G, Maldonado H, Lafourcade C, Delorenzi A, Romano A | title = Kappa-B like DNA-binding activity is enhanced after spaced training that induces long-term memory in the crab Chasmagnathus | journal = Neuroscience Letters | volume = 242 | issue = 3 | pages = 143–6 | date = February 1998 | pmid = 9530926 | doi = 10.1016/S0304-3940(98)00059-7 }}</ref><ref name="Merlo_2002">{{cite journal | vauthors = Merlo E, Freudenthal R, Romano A | title = The IkappaB kinase inhibitor sulfasalazine impairs long-term memory in the crab Chasmagnathus | journal = Neuroscience | volume = 112 | issue = 1 | pages = 161–72 | year = 2002 | pmid = 12044481 | doi = 10.1016/S0306-4522(02)00049-0 }}</ref><ref name="Toxicol Ind Health">{{cite journal | vauthors = Park HJ, Youn HS | title = Mercury induces the expression of cyclooxygenase-2 and inducible nitric oxide synthase | journal = Toxicology and Industrial Health | volume = 29 | issue = 2 | pages = 169–74 | date = March 2013 | pmid = 22080037 | doi = 10.1177/0748233711427048 }}</ref> |
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'''NF-κB''' ({{lang-en|nuclear factor kappa-light-chain-enhancer of activated B cells, nuclear factor-kappaB}}) adalah keluarga [[faktor transkripsi]] yang berperan dalam pertumbuhan kardiovaskular, respon stres, dan [[peradangan]], [[sistem kekebalan tiruan]], [[sistem kekebalan turunan]], [[apoptosis]], dengan mengendalikan ekspresi genetik.<ref>{{en}}{{cite web |
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| url = http://www.ncbi.nlm.nih.gov/pubmed/17303919 |
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| title = The NF-kappaB regulatory network |
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| accessdate = 2010-10-18 |
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| work = Department of Internal Medicine and Sealy Center for Molecular Sciences, University of Texas Medical Branch; Brasier AR. |
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}}</ref> |
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== Penemuan == |
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Gangguan fungsi pada NF-κB atau [[inhibitor NF-kappaB kinase|IKK]] dapat menyebabkan berbagai penyakit termasuk [[kanker]].<ref>{{en}}{{cite web |
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NF-κB ditemukan oleh Dr. Ranjan Sen di laboratorium penerima Hadiah Nobel David Baltimore melalui interaksinya dengan urutan pasangan 11 basa pada enhancer rantai ringan imunoglobulin pada sel B.<ref name="pmid3091258">{{cite journal | vauthors = Sen R, Baltimore D | title = Multiple nuclear factors interact with the immunoglobulin enhancer sequences | journal = Cell | volume = 46 | issue = 5 | pages = 705–16 | date = August 1986 | pmid = 3091258 | doi = 10.1016/0092-8674(86)90346-6 }}</ref> |
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| url = http://www.ncbi.nlm.nih.gov/pubmed/17183360 |
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| title = Integrating cell-signalling pathways with NF-kappaB and IKK function |
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| accessdate = 2010-10-18 |
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| work = College of Life Sciences, Division of Gene Regulation and Expression, James Black Centre; Perkins ND |
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}}</ref> |
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Protein NF-kB secara normal berada sebagai komponen yang tidak aktif, dengan terikat pada protein IkB. |
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Sejak ditemukan pada tahun 1986, banyak studi menunjukkan hubungan antara lintasan [[transduksi sinyal selular|sinyal]] NF-κB dan respon peradangan:<ref>{{en}}{{cite web |
Sejak ditemukan pada tahun 1986, banyak studi menunjukkan hubungan antara lintasan [[transduksi sinyal selular|sinyal]] NF-κB dan respon peradangan:<ref>{{en}}{{cite web |
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| url = http://www.ncbi.nlm.nih.gov/pubmed/17355113 |
| url = http://www.ncbi.nlm.nih.gov/pubmed/17355113 |
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Revisi per 9 Juni 2017 21.41
NF-κB (Inggris: nuclear factor kappa-light-chain-enhancer of activated B cells, nuclear factor-kappaB) adalah keluarga faktor transkripsi yang berperan dalam respon seluler terhadap rangsangan seperti stres, sitokina, radikal bebas, logam berat, iradiasi ultraviolet, LDL yang teroksidasi, dan bakteri atau virus (antigen).[1][2][3][4][5] NF-κB memainkan peran kunci dalam mengatur respon imun terhadap infeksi (rantai ringan κ adalah komponen penting imunoglobulin). Regulasi NF-κB yang salah telah dikaitkan dengan kanker, inflamasi dan penyakit autoimun, syok septik, infeksi virus, dan gangguan sistem imun. NF-κB juga terlibat dalam proses plastisitas sinaptik dan memori.[6][7][8][9][10][11]
Penemuan
NF-κB ditemukan oleh Dr. Ranjan Sen di laboratorium penerima Hadiah Nobel David Baltimore melalui interaksinya dengan urutan pasangan 11 basa pada enhancer rantai ringan imunoglobulin pada sel B.[12] Sejak ditemukan pada tahun 1986, banyak studi menunjukkan hubungan antara lintasan sinyal NF-κB dan respon peradangan:[13]
- Lintasan yang pertama dipicu oleh respon terhadap infeksi mikrobial dan viral, atau paparan sitokina yang mengaktivasi kompleks IKK, yang menginduksi fosforilasi dan degradasi IkappaB.
- Lintasan yang kedua dipicu oleh sitokina dari keluarga faktor nekrosis tumor melalui aktivasi kinase NIK, lalu homodimer IKKalfa. Pencerap TNF-1 (TNF-R1) merupakan pencerap apoptosis dengan dua kompleks sinyal. Kompleks I terbentuk pada membran sel, sedangkan kompleks II terbentuk di dalam sitoplasma. Kompleks I akan berupaya untuk mengaktivasi NF-κB sedangkan kompleks II akan melakukan transduksi sinyal apoptosis saat NF-κB tidak dapat meningkatkan rasio anti-apoptotik FLIPL.[14]
- Lintasan yang ketiga NF-κB memicu transkripsi protein anti-apoptosis, tanpa pengaruh CK2 dan IKK, sehingga meningkatkan proliferasi sel dan tumor. Beberapa senyawa seperti aspirin dan kortikosteroid diketahui merupakan inhibitor NF-κB.
Rujukan
- ^ Gilmore TD (October 2006). "Introduction to NF-kappaB: players, pathways, perspectives". Oncogene. 25 (51): 6680–4. doi:10.1038/sj.onc.1209954. PMID 17072321.
- ^ Brasier AR (2006). "The NF-kappaB regulatory network". Cardiovascular Toxicology. 6 (2): 111–30. doi:10.1385/CT:6:2:111. PMID 17303919.
- ^ Perkins ND (January 2007). "Integrating cell-signalling pathways with NF-kappaB and IKK function". Nature Reviews Molecular Cell Biology. 8 (1): 49–62. doi:10.1038/nrm2083. PMID 17183360.
- ^ Gilmore TD (November 1999). "The Rel/NF-kappaB signal transduction pathway: introduction". Oncogene. 18 (49): 6842–4. doi:10.1038/sj.onc.1203237. PMID 10602459.
- ^ Tian B, Brasier AR (2003). "Identification of a nuclear factor kappa B-dependent gene network". Recent Progress in Hormone Research. 58: 95–130. doi:10.1210/rp.58.1.95. PMID 12795416.
- ^ Albensi BC, Mattson MP (February 2000). "Evidence for the involvement of TNF and NF-kappaB in hippocampal synaptic plasticity". Synapse. 35 (2): 151–9. doi:10.1002/(SICI)1098-2396(200002)35:2<151::AID-SYN8>3.0.CO;2-P. PMID 10611641.
- ^ Meffert MK, Chang JM, Wiltgen BJ, Fanselow MS, Baltimore D (October 2003). "NF-kappa B functions in synaptic signaling and behavior". Nature Neuroscience. 6 (10): 1072–8. doi:10.1038/nn1110. PMID 12947408.
- ^ Levenson JM, Choi S, Lee SY, Cao YA, Ahn HJ, Worley KC, Pizzi M, Liou HC, Sweatt JD (April 2004). "A bioinformatics analysis of memory consolidation reveals involvement of the transcription factor c-rel". The Journal of Neuroscience. 24 (16): 3933–43. doi:10.1523/JNEUROSCI.5646-03.2004. PMID 15102909.
- ^ Freudenthal R, Locatelli F, Hermitte G, Maldonado H, Lafourcade C, Delorenzi A, Romano A (February 1998). "Kappa-B like DNA-binding activity is enhanced after spaced training that induces long-term memory in the crab Chasmagnathus". Neuroscience Letters. 242 (3): 143–6. doi:10.1016/S0304-3940(98)00059-7. PMID 9530926.
- ^ Merlo E, Freudenthal R, Romano A (2002). "The IkappaB kinase inhibitor sulfasalazine impairs long-term memory in the crab Chasmagnathus". Neuroscience. 112 (1): 161–72. doi:10.1016/S0306-4522(02)00049-0. PMID 12044481.
- ^ Park HJ, Youn HS (March 2013). "Mercury induces the expression of cyclooxygenase-2 and inducible nitric oxide synthase". Toxicology and Industrial Health. 29 (2): 169–74. doi:10.1177/0748233711427048. PMID 22080037.
- ^ Sen R, Baltimore D (August 1986). "Multiple nuclear factors interact with the immunoglobulin enhancer sequences". Cell. 46 (5): 705–16. doi:10.1016/0092-8674(86)90346-6. PMID 3091258.
- ^ (Inggris)"The transcription factor nuclear factor-kappa B and cancer". Surgical Oncology Unit, Hospital de Especialidades; Escárcega RO, Fuentes-Alexandro S, García-Carrasco M, Gatica A, Zamora A. Diakses tanggal 2010-10-18.
- ^ (Inggris)"Death receptor activation complexes: it takes two to activate TNF receptor 1". Department of Pharmacology, SUNY, Upstate Medical University; Sheikh MS, Huang Y. Diakses tanggal 2010-10-18.
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