TXNIP

TXNIP
Struktur yang tersedia
PDB	Pencarian Ortolog: PDBe RCSB
Daftar kode id PDB
	4GEI, 4GEJ, 4GFX, 4LL1, 4LL4, 4ROF, 4ROJ, 5CQ2, 5DF6, 5DWS, 5DZD
Pengidentifikasi
Alias	TXNIP, thioredoxin interacting protein, EST01027, HHCPA78, THIF, VDUP1, ARRDC6
ID eksternal	OMIM: 606599 MGI: 1889549 HomoloGene: 38186 GeneCards: TXNIP
Lokasi gen (Tikus)
Kr.	Kromosom 3 (tikus)
Akhir	96,469,199 bp
Pola ekspresi RNA
	; ; ; ;
	Referensi data ekspresi selengkapnya
Ontologi gen
Fungsi molekuler	• GO:0048551 enzyme inhibitor activity; • GO:0001948, GO:0016582 Ikatan protein plasma; • ubiquitin protein ligase binding;
Komponen seluler	• sitoplasma; • sitosol; • mitochondrial intermembrane space; • Inti sel;
Proses biologis	• cellular response to tumor cell; • response to estradiol; • GO:0048553 negative regulation of catalytic activity; • GO:0009373 regulation of transcription, DNA-templated; • protein import into nucleus; • response to progesterone; • response to mechanical stimulus; • GO:1901227 negative regulation of transcription by RNA polymerase II; • response to glucose; • GO:0001306 response to oxidative stress; • transcription, DNA-templated; • keratinocyte differentiation; • response to calcium ion; • negative regulation of cell division; • regulation of cell population proliferation; • positive regulation of apoptotic process; • Siklus sel; • platelet-derived growth factor receptor signaling pathway; • respons terhadap hidrogen peroksida; • GO:0072468 signal transduction;
	Sumber:Amigo / QuickGO
Ortolog
	10628
	56338
	ENSG00000265972
	ENSMUSG00000038393
	Q9H3M7
	Q8BG60
	NM_006472; NM_001313972
	NM_001009935; NM_023719
	NP_001300901; NP_006463
	NP_001009935; NP_076208
	Wikidata
Lihat/Sunting Manusia	Lihat/Sunting Tikus

Protein penginteraksi-tioredoksin (Inggris: Thioredoxin-interacting protein, TXNIP) adalah protein pada manusia yang disandi oleh gen TXNIP^[4]^[5]

Interaksi[sunting | sunting sumber]

TXNIP telah menunjukkan berinteraksi dengan tioredoksin^[6] dan ZBTB32.^[7]

Fungsi[sunting | sunting sumber]

TXNIP memiliki kemampuan menghambat proliferasi sel dan merupakan penekan tumor yang dikenal sering tidak aktif pada kanker. Saat ini terungkap bahwa TXNIP adalah target hilir sinyal IGF-1/IGF-1R, yang mana ekspresi TXNIP menurun dengan perlakuan IGF-1, sesuai dengan model bahwa hilangnya TXNIP bertanggung jawab atas aksi antiapoptosis IGF-1. Oleh karena itu, peningkatan kadar TXNIP pada pasien sindrom Laron (LS) mungkin bertanggung jawab atas perlindungan terhadap kanker pada populasi ini dan bahwa TXNIP dapat berfungsi sebagai penanda biologis masa depan yang memungkinkan prediksi respons terhadap penghambatan IGF-1R atau untuk memantau terapi penghambat IGF-1R.^[8]

Referensi[sunting | sunting sumber]

^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000038393 - Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Chen KS, DeLuca HF (Sep 1994). "Isolation and characterization of a novel cDNA from HL-60 cells treated with 1,25-dihydroxyvitamin D-3". Biochimica et Biophysica Acta. 1219 (1): 26–32. doi:10.1016/0167-4781(94)90242-9. PMID 8086474.
^ "Entrez Gene: TXNIP thioredoxin interacting protein".
^ Nishiyama A, Matsui M, Iwata S, Hirota K, Masutani H, Nakamura H, Takagi Y, Sono H, Gon Y, Yodoi J (Jul 1999). "Identification of thioredoxin-binding protein-2/vitamin D(3) up-regulated protein 1 as a negative regulator of thioredoxin function and expression". The Journal of Biological Chemistry. 274 (31): 21645–50. doi:10.1074/jbc.274.31.21645. PMID 10419473.
^ Han SH, Jeon JH, Ju HR, Jung U, Kim KY, Yoo HS, Lee YH, Song KS, Hwang HM, Na YS, Yang Y, Lee KN, Choi I (Jun 2003). "VDUP1 upregulated by TGF-beta1 and 1,25-dihydorxyvitamin D3 inhibits tumor cell growth by blocking cell-cycle progression". Oncogene. 22 (26): 4035–46. doi:10.1038/sj.onc.1206610. PMID 12821938.
^ Nagaraj K, Lapkina-Gendler L, Sarfstein R, Gurwitz D, Pasmanik-Chor M, Laron Z, Yakar S, Werner H (Feb 2018). "Identification of thioredoxin-interacting protein (TXNIP) as a downstream target for IGF1 action". Proc Natl Acad Sci U S A. 115 (5): 1045–50. doi:10.1073/pnas.1715930115. PMID 29339473. Galat gaya Vancouver: punctuation (bantuan)

[refGRCm38Ensembl-1] GRCm38: Ensembl release 89: ENSMUSG00000038393 - Ensembl, May 2017

[2] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[3] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid8086474-4] Chen KS, DeLuca HF (Sep 1994). "Isolation and characterization of a novel cDNA from HL-60 cells treated with 1,25-dihydroxyvitamin D-3". Biochimica et Biophysica Acta. 1219 (1): 26–32. doi:10.1016/0167-4781(94)90242-9. PMID 8086474.

[entrez-5] "Entrez Gene: TXNIP thioredoxin interacting protein".

[PMID10419473-6] Nishiyama A, Matsui M, Iwata S, Hirota K, Masutani H, Nakamura H, Takagi Y, Sono H, Gon Y, Yodoi J (Jul 1999). "Identification of thioredoxin-binding protein-2/vitamin D(3) up-regulated protein 1 as a negative regulator of thioredoxin function and expression". The Journal of Biological Chemistry. 274 (31): 21645–50. doi:10.1074/jbc.274.31.21645. PMID 10419473.

[PMID12821938-7] Han SH, Jeon JH, Ju HR, Jung U, Kim KY, Yoo HS, Lee YH, Song KS, Hwang HM, Na YS, Yang Y, Lee KN, Choi I (Jun 2003). "VDUP1 upregulated by TGF-beta1 and 1,25-dihydorxyvitamin D3 inhibits tumor cell growth by blocking cell-cycle progression". Oncogene. 22 (26): 4035–46. doi:10.1038/sj.onc.1206610. PMID 12821938.

[PMID29339473-8] Nagaraj K, Lapkina-Gendler L, Sarfstein R, Gurwitz D, Pasmanik-Chor M, Laron Z, Yakar S, Werner H (Feb 2018). "Identification of thioredoxin-interacting protein (TXNIP) as a downstream target for IGF1 action". Proc Natl Acad Sci U S A. 115 (5): 1045–50. doi:10.1073/pnas.1715930115. PMID 29339473. Galat gaya Vancouver: punctuation (bantuan)

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