Isokonazol

Isokonazol
Data klinis
AHFS/Drugs.com	International Drug Names
Kode ATC	D01AC05 (WHO) G01AF07;
Pengenal
	Nama IUPAC (RS)-1-[2-[(2,6-Diklorobenzil)oksi]-2-(2,4-diklorofenil)etil]-1H-imidazola;
Nomor CAS	27523-40-6;
PubChem CID	3760;
DrugBank	DB08943 ;
ChemSpider	3629;
UNII	GRI7WFR424;
KEGG	D04624;
ChEBI	CHEBI:82865 ;
ChEMBL	ChEMBL1571863;
CompTox Dashboard (EPA)	DTXSID7045447 ;
ECHA InfoCard	100.044.084
Data sifat kimia dan fisik
Rumus	C18H14Cl4N2O
Massa molar	416,12 g·mol−1
Model 3D (JSmol)	Gambar interaktif;
	SMILES Clc1ccc(c(Cl)c1)C(OCc2c(Cl)cccc2Cl)Cn3ccnc3;

Isokonazol adalah obat antijamur azola dan dapat menghambat bakteri gram-positif.^[1]^[2] Untuk infeksi kaki dan vagina, isokonazol memiliki efektivitas yang sama dengan klotrimazol.^[3]^[4] Isokonazol nitrat dapat digunakan dalam kombinasi dengan kortikosteroid diflukortolon untuk meningkatkan bioavailabilitasnya.^[1] Obat ini dipatenkan pada tahun 1968 dan disetujui untuk penggunaan medis pada tahun 1979.^[5]

Referensi

1 2 Veraldi S (May 2013). "Isoconazole nitrate: a unique broad-spectrum antimicrobial azole effective in the treatment of dermatomycoses, both as monotherapy and in combination with corticosteroids". Mycoses. 56 (Suppl 1): 3–15. doi:10.1111/myc.12054. PMID 23574019. S2CID 1881151.
↑ Budavari S, O'Neil M, Smith A, Heckelman P, Obenchain J (1996). "Isoconazole". Dalam Budavari S (ed.). The Merck Index (Edisi 12th). hlm. 5176. ISBN 0-911910-12-3.
↑ Oyeka CA, Gugnani HC (1992). "Isoconazole nitrate versus clotrimazole in foot and nail infections due to Hendersonula toruloidea, Scytalidium hyalinum and dermatophytes". Mycoses. 35 (11–12): 357–361. doi:10.1111/j.1439-0507.1992.tb00894.x. PMID 1302811. S2CID 6764090.
↑ Cohen L (February 1984). "Single dose treatment of vaginal candidosis: comparison of clotrimazole and isoconazole". The British Journal of Venereal Diseases. 60 (1): 42–44. doi:10.1136/sti.60.1.42. PMC 1046268. PMID 6365236.
↑ Fischer J, Ganellin CR (2006). Analogue-based Drug Discovery (dalam bahasa Inggris). John Wiley & Sons. hlm. 502. ISBN 9783527607495.

[Veraldi2013-1] 1 2 Veraldi S (May 2013). "Isoconazole nitrate: a unique broad-spectrum antimicrobial azole effective in the treatment of dermatomycoses, both as monotherapy and in combination with corticosteroids". Mycoses. 56 (Suppl 1): 3–15. doi:10.1111/myc.12054. PMID 23574019. S2CID 1881151.

[2] Budavari S, O'Neil M, Smith A, Heckelman P, Obenchain J (1996). "Isoconazole". Dalam Budavari S (ed.). The Merck Index (Edisi 12th). hlm. 5176. ISBN 0-911910-12-3.

[Oyeka1992-3] Oyeka CA, Gugnani HC (1992). "Isoconazole nitrate versus clotrimazole in foot and nail infections due to Hendersonula toruloidea, Scytalidium hyalinum and dermatophytes". Mycoses. 35 (11–12): 357–361. doi:10.1111/j.1439-0507.1992.tb00894.x. PMID 1302811. S2CID 6764090.

[Cohen1984-4] Cohen L (February 1984). "Single dose treatment of vaginal candidosis: comparison of clotrimazole and isoconazole". The British Journal of Venereal Diseases. 60 (1): 42–44. doi:10.1136/sti.60.1.42. PMC 1046268. PMID 6365236.

[Fischer2006-5] Fischer J, Ganellin CR (2006). Analogue-based Drug Discovery (dalam bahasa Inggris). John Wiley & Sons. hlm. 502. ISBN 9783527607495.

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