ENDOG

ENDOG
Pengidentifikasi
Alias	ENDOG, endonuclease G
ID eksternal	OMIM: 600440 MGI: 1261433 HomoloGene: 55823 GeneCards: ENDOG
Lokasi gen (Tikus)
Kr.	Kromosom 2 (tikus)
Akhir	30,064,081 bp
Pola ekspresi RNA
	Referensi data ekspresi selengkapnya
Ontologi gen
Fungsi molekuler	• deoxyribonuclease activity; • metal ion binding; • GO:0001948, GO:0016582 Ikatan protein plasma; • nucleic acid binding; • nuclease activity; • endonuclease activity; • hydrolase activity; • single-stranded DNA endodeoxyribonuclease activity; • endoribonuclease activity; • exodeoxyribonuclease activity;
Komponen seluler	• sitosol; • perikaryon; • mitokondria; • Inti sel; • mitochondrial inner membrane;
Proses biologis	• cellular response to calcium ion; • positive regulation of apoptotic DNA fragmentation; • DNA recombination; • apoptotic DNA fragmentation; • response to estradiol; • GO:1904576 response to antibiotic; • response to mechanical stimulus; • GO:0010260 penuaan; • in utero embryonic development; • response to tumor necrosis factor; • neuron death in response to oxidative stress; • positive regulation of apoptotic process; • cellular response to oxidative stress; • respons seluler terhadap hipoksia; • cellular response to glucose stimulus; • positive regulation of hydrogen peroxide-mediated programmed cell death; • DNA catabolic process, endonucleolytic; • RNA phosphodiester bond hydrolysis, endonucleolytic;
	Sumber:Amigo / QuickGO
Ortolog
	2021
	13804
	ENSG00000167136
	ENSMUSG00000015337
	Q14249
	O08600
	NM_004435
	NM_007931
	NP_004426
	NP_031957
	Wikidata
Lihat/Sunting Manusia	Lihat/Sunting Tikus

Endonuklease G, mitokondrial adalah enzim yang pada manusia disandikan oleh gen ENDOG.^[4]^[5] Protein ini terutama berperan dalam apoptosis independen caspase melalui degradasi DNA ketika terjadi translokasi dari mitokondria ke nukleus di bawah stres oksidatif.^[6] Akibatnya, EndoG telah terlibat dalam kanker, penuaan, dan penyakit neurodegeneratif seperti penyakit Parkinson (PD). Regulasi tingkat ekspresi gen ini memiliki potensi untuk mengobati atau memperbaiki kondisi medis tersebut.^[6]^[6]^[7]

Referensi[sunting | sunting sumber]

^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000015337 - Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Tiranti V, Rossi E, Ruiz-Carrillo A, Rossi G, Rocchi M, DiDonato S, Zuffardi O, Zeviani M (Jan 1995). "Chromosomal localization of mitochondrial transcription factor A (TCF6), single-stranded DNA-binding protein (SSBP), and endonuclease G (ENDOG), three human housekeeping genes involved in mitochondrial biogenesis". Genomics. 25 (2): 559–64. doi:10.1016/0888-7543(95)80058-T. PMID 7789991.
^ "Entrez Gene: ENDOG endonuclease G".
^ ^a ^b ^c Vařecha M, Potěšilová M, Matula P, Kozubek M (Apr 2012). "Endonuclease G interacts with histone H2B and DNA topoisomerase II alpha during apoptosis". Molecular and Cellular Biochemistry. 363 (1–2): 301–7. doi:10.1007/s11010-011-1182-x. PMID 22160858.
^ Büttner S, Habernig L, Broeskamp F, Ruli D, Vögtle FN, Vlachos M, Macchi F, Küttner V, Carmona-Gutierrez D, Eisenberg T, Ring J, Markaki M, Taskin AA, Benke S, Ruckenstuhl C, Braun R, Van den Haute C, Bammens T, van der Perren A, Fröhlich KU, Winderickx J, Kroemer G, Baekelandt V, Tavernarakis N, Kovacs GG, Dengjel J, Meisinger C, Sigrist SJ, Madeo F (Nov 2013). "Endonuclease G mediates α-synuclein cytotoxicity during Parkinson's disease". The EMBO Journal. 32 (23): 3041–54. doi:10.1038/emboj.2013.228. PMC 3844953 . PMID 24129513.

Bacaan lanjutan[sunting | sunting sumber]

Prats E, Noël M, Létourneau J, Tiranti V, Vaqué J, Debón R, Zeviani M, Cornudella L, Ruiz-Carrillo A (Sep 1997). "Characterization and expression of the mouse endonuclease G gene". DNA and Cell Biology. 16 (9): 1111–22. doi:10.1089/dna.1997.16.1111. PMID 9324313.
Li LY, Luo X, Wang X (Jul 2001). "Endonuclease G is an apoptotic DNase when released from mitochondria". Nature. 412 (6842): 95–9. doi:10.1038/35083620. PMID 11452314.
Ohsato T, Ishihara N, Muta T, Umeda S, Ikeda S, Mihara K, Hamasaki N, Kang D (Dec 2002). "Mammalian mitochondrial endonuclease G. Digestion of R-loops and localization in intermembrane space". European Journal of Biochemistry / FEBS. 269 (23): 5765–70. doi:10.1046/j.1432-1033.2002.03238.x . PMID 12444964.
Lemarié A, Lagadic-Gossmann D, Morzadec C, Allain N, Fardel O, Vernhet L (Jun 2004). "Cadmium induces caspase-independent apoptosis in liver Hep3B cells: role for calcium in signaling oxidative stress-related impairment of mitochondria and relocation of endonuclease G and apoptosis-inducing factor". Free Radical Biology & Medicine. 36 (12): 1517–31. doi:10.1016/j.freeradbiomed.2004.03.020. PMID 15182854.
Singh IN, Goody RJ, Dean C, Ahmad NM, Lutz SE, Knapp PE, Nath A, Hauser KF (Jun 2004). "Apoptotic death of striatal neurons induced by human immunodeficiency virus-1 Tat and gp120: Differential involvement of caspase-3 and endonuclease G". Journal of Neurovirology. 10 (3): 141–51. doi:10.1080/13550280490441103. PMC 4309288 . PMID 15204919.
Kalinowska M, Garncarz W, Pietrowska M, Garrard WT, Widlak P (Aug 2005). "Regulation of the human apoptotic DNase/RNase endonuclease G: involvement of Hsp70 and ATP". Apoptosis. 10 (4): 821–30. doi:10.1007/s10495-005-0410-9. PMID 16133872.
Basnakian AG, Apostolov EO, Yin X, Abiri SO, Stewart AG, Singh AB, Shah SV (Dec 2006). "Endonuclease G promotes cell death of non-invasive human breast cancer cells". Experimental Cell Research. 312 (20): 4139–49. doi:10.1016/j.yexcr.2006.09.012. PMC 1839947 . PMID 17046751.
Whiteman M, Chu SH, Siau JL, Rose P, Sabapathy K, Schantz JT, Cheung NS, Spencer JP, Armstrong JS (Apr 2007). "The pro-inflammatory oxidant hypochlorous acid induces Bax-dependent mitochondrial permeabilisation and cell death through AIF-/EndoG-dependent pathways". Cellular Signalling. 19 (4): 705–14. doi:10.1016/j.cellsig.2006.08.019. PMID 17107772.
Varecha M, Amrichová J, Zimmermann M, Ulman V, Lukásová E, Kozubek M (Jul 2007). "Bioinformatic and image analyses of the cellular localization of the apoptotic proteins endonuclease G, AIF, and AMID during apoptosis in human cells". Apoptosis. 12 (7): 1155–71. doi:10.1007/s10495-007-0061-0. PMID 17347867.

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[refGRCm38Ensembl-1] GRCm38: Ensembl release 89: ENSMUSG00000015337 - Ensembl, May 2017

[2] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[3] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid7789991-4] Tiranti V, Rossi E, Ruiz-Carrillo A, Rossi G, Rocchi M, DiDonato S, Zuffardi O, Zeviani M (Jan 1995). "Chromosomal localization of mitochondrial transcription factor A (TCF6), single-stranded DNA-binding protein (SSBP), and endonuclease G (ENDOG), three human housekeeping genes involved in mitochondrial biogenesis". Genomics. 25 (2): 559–64. doi:10.1016/0888-7543(95)80058-T. PMID 7789991.

[entrez-5] "Entrez Gene: ENDOG endonuclease G".

[pmid22160858-6] Vařecha M, Potěšilová M, Matula P, Kozubek M (Apr 2012). "Endonuclease G interacts with histone H2B and DNA topoisomerase II alpha during apoptosis". Molecular and Cellular Biochemistry. 363 (1–2): 301–7. doi:10.1007/s11010-011-1182-x. PMID 22160858.

[pmid24129513-7] Büttner S, Habernig L, Broeskamp F, Ruli D, Vögtle FN, Vlachos M, Macchi F, Küttner V, Carmona-Gutierrez D, Eisenberg T, Ring J, Markaki M, Taskin AA, Benke S, Ruckenstuhl C, Braun R, Van den Haute C, Bammens T, van der Perren A, Fröhlich KU, Winderickx J, Kroemer G, Baekelandt V, Tavernarakis N, Kovacs GG, Dengjel J, Meisinger C, Sigrist SJ, Madeo F (Nov 2013). "Endonuclease G mediates α-synuclein cytotoxicity during Parkinson's disease". The EMBO Journal. 32 (23): 3041–54. doi:10.1038/emboj.2013.228. PMC 3844953 . PMID 24129513.

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